Evidence map›Paper›PMID 38878555›Full record

ReviewArtificial intelligence in medicine2024

Transformers and large language models in healthcare: A review.

Subhash Nerella, Sabyasachi Bandyopadhyay, Jiaqing Zhang, Miguel Contreras, Scott Siegel, Aysegul Bumin, Brandon Silva, Jessica Sena, Benjamin Shickel, Azra Bihorac and 2 more

Abstract readReview
In one paragraph

Review in Artificial intelligence in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Article
  5. Article
  6. Article
  7. Large language models in spine care and research.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Review
  8. Article
  9. Observational
  10. Article
  11. Article
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  13. Article
  14. Article
  15. Review
  16. Article
  17. AI-assisted tumor board decision-making in pancreatic oncology.BMC medical informatics and decision making · 2026
    Article
  18. Article
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Subhash NerellaDepartment of Biomedical Engineering, University of Florida, Gainesville, United States.
Sabyasachi BandyopadhyayDepartment of Medicine, Stanford University, Stanford, United States.
Jiaqing ZhangDepartment of Electrical and Computer Engineering, University of Florida, Gainesville, United States.
Miguel ContrerasDepartment of Biomedical Engineering, University of Florida, Gainesville, United States.
Scott SiegelDepartment of Biomedical Engineering, University of Florida, Gainesville, United States.
Aysegul BuminDepartment of Computer and Information Science and Engineering, University of Florida, Gainesville, United States.
Brandon SilvaDepartment of Computer and Information Science and Engineering, University of Florida, Gainesville, United States.
Jessica SenaDepartment Of Computer Science, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Benjamin ShickelDepartment of Medicine, University of Florida, Gainesville, United States.
Azra BihoracDepartment of Medicine, University of Florida, Gainesville, United States.
Kia KhezeliDepartment of Biomedical Engineering, University of Florida, Gainesville, United States.
Parisa RashidiDepartment of Biomedical Engineering, University of Florida, Gainesville, United States. Electronic address: parisa.rashidi@ufl.edu.

Funding

ADAPT: Autonomous Delirium Monitoring and Adaptive PreventionR01NS120924 · NINDS · UNIVERSITY OF FLORIDA · PI BIHORAC, AZRA, RASHIDI, PARISA · 2021 to 2025
$2.9M
Intelligent Intensive Care Unit (I2CU): Pervasive Sensing and Artificial Intelligence for Augmented Clinical Decision-makingR01EB029699 · NIBIB · UNIVERSITY OF FLORIDA · PI BIHORAC, AZRA, RASHIDI, PARISA · 2021 to 2024
$2.4M
NIBIB NIH HHS R01 EB029699NINDS NIH HHS R01 NS120924
6 · The paper itself

Abstract

With Artificial Intelligence (AI) increasingly permeating various aspects of society, including healthcare, the adoption of the Transformers neural network architecture is rapidly changing many applications. Transformer is a type of deep learning architecture initially developed to solve general-purpose Natural Language Processing (NLP) tasks and has subsequently been adapted in many fields, including healthcare. In this survey paper, we provide an overview of how this architecture has been adopted to analyze various forms of healthcare data, including clinical NLP, medical imaging, structured Electronic Health Records (EHR), social media, bio-physiological signals, biomolecular sequences. Furthermore, which have also include the articles that used the transformer architecture for generating surgical instructions and predicting adverse outcomes after surgeries under the umbrella of critical care. Under diverse settings, these models have been used for clinical diagnosis, report generation, data reconstruction, and drug/protein synthesis. Finally, we also discuss the benefits and limitations of using transformers in healthcare and examine issues such as computational cost, model interpretability, fairness, alignment with human values, ethical implications, and environmental impact.

Indexed as

Deep LearningNatural Language ProcessingArtificial IntelligenceDelivery of Health CareElectronic Health RecordsHumansNeural Networks, ComputerElectronic Health RecordsHealthcareLarge Language ModelsMedical ImagingNatural Language ProcessingTransformers

Identifiers

PMID38878555
PMCPMC11638972

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.