ArticleHuman brain mapping2024
Network enrichment significance testing in brain-phenotype association studies.
Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity.Brain structure & function · 2026Article
- Shared neurogenetic architecture links adolescent neurodevelopmental deviations to adult psychopathological procrastination.Molecular psychiatry · 2026Article
- Brain energetic landscapes shape state dysregulation in major depressive disorder: a morphological network controllability perspective.Translational psychiatry · 2026Article
- Testing for Network Specificity in Brain-Behavior Associations Using Ordinal Dominance Curves.Human brain mapping · 2026Article
- Two axes of white matter development.Nature communications · 2026Article
- A proof-of-concept application of gene set enrichment analysis principles to olfactory phenotyping in Parkinson's disease.Frontiers in neuroscience · 2026Article
- Uncovering functional connectivity patterns predictive of cognition in youth using interpretable predictive modeling.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Diverging network architecture of theArXiv · 2025Article
- Mapping Individual Differences in Intermodal Coupling in Neurodevelopment.bioRxiv : the preprint server for biology · 2025Article
- Harmonizing network-based statistics across different atlases in brain connectome analysis.Communications biology · 2025Article
- Statistical properties of functional connectivity MRI enrichment analysis in school-age autism research.Developmental cognitive neuroscience · 2025Article
- Mapping individual differences in intermodal coupling in neurodevelopment.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- The effect of spherical projection on spin tests for brain maps.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Neuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence.JAMA network open · 2024Article
- Network enrichment significance testing in brain-phenotype association studies.Human brain mapping · 2024Article
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15 authors.
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Abstract
Functional networks often guide our interpretation of spatial maps of brain-phenotype associations. However, methods for assessing enrichment of associations within networks of interest have varied in terms of both scientific rigor and underlying assumptions. While some approaches have relied on subjective interpretations, others have made unrealistic assumptions about spatial properties of imaging data, leading to inflated false positive rates. We seek to address this gap in existing methodology by borrowing insight from a method widely used in genetics research for testing enrichment of associations between a set of genes and a phenotype of interest. We propose network enrichment significance testing (NEST), a flexible framework for testing the specificity of brain-phenotype associations to functional networks or other sub-regions of the brain. We apply NEST to study enrichment of associations with structural and functional brain imaging data from a large-scale neurodevelopmental cohort study.
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