Evidence map›Paper›PMID 38878223›Full record

ArticleMolecular and cellular biochemistry2025

RNF144A-AS1 stabilizes TAF15 and promotes malignant biological behaviors of skin cutaneous melanoma.

Shude Yang, Yudi Sun, Ning Wang, Ziming Yang, Hao Xing, Jialin Jia

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Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shude Yang *Department of Plastic Surgery, The First Hospital of China Medical University, No.155 Nanjing North Street, Heping District, 110001, Shenyang, Liaoning Province, People's Republic of China. sdyang@cmu.edu.cn.
Yudi Sun *Department of Plastic Surgery, The First Hospital of China Medical University, No.155 Nanjing North Street, Heping District, 110001, Shenyang, Liaoning Province, People's Republic of China.
Ning WangDepartment of Plastic Surgery, The First Hospital of China Medical University, No.155 Nanjing North Street, Heping District, 110001, Shenyang, Liaoning Province, People's Republic of China.
Ziming YangDepartment of Plastic Surgery, The First Hospital of China Medical University, No.155 Nanjing North Street, Heping District, 110001, Shenyang, Liaoning Province, People's Republic of China.
Hao XingDepartment of Plastic Surgery, The First Hospital of China Medical University, No.155 Nanjing North Street, Heping District, 110001, Shenyang, Liaoning Province, People's Republic of China.
Jialin JiaDepartment of Plastic Surgery, The First Hospital of China Medical University, No.155 Nanjing North Street, Heping District, 110001, Shenyang, Liaoning Province, People's Republic of China.

Funding

China Postdoctoral Science Foundation 2020M681020Natural Science Foundation of Liaoning Province 2021-BS-103
6 · The paper itself

Abstract

LncRNAs have been demonstrated to regulate biological processes in malignant tumors. In our previous study, we identified the immune-related LncRNA RNF144A-AS1 as a potential regulator in SKCM. However, its precise function and regulatory mechanism remain unclear. In this study, we observed upregulation of RNF144A-AS1 in SKCM and found that knockdown of RNF144A-AS1 suppressed proliferation, migration, invasion, and epithelial-mesenchymal transition abilities of melanoma cells. Mechanistically, as a high-risk prognostic factor, RNF144A-AS1 regulated biological processes of SKCM by interacting with TAF15 through an RNA-binding protein-dependent (RBP-dependent) manner. Furthermore, we confirmed that TAF15 activated downstream transcriptional regulation of YAP1 to modulate malignant behaviors in melanoma cells. In vivo experiments revealed that knockdown of RNF144A-AS1 inhibited tumorigenic capacity of melanoma cells and exhibited promising therapeutic effects. Collectively, these findings highlight the significance of the RNF144A-AS1/TAF15/YAP1 axis in promoting malignant behaviors in SKCM and provide novel insights into potential prognostic biomarkers and therapeutic targets for this disease.

Indexed as

Gene Expression Regulation, NeoplasticMelanomaNeoplasm ProteinsRNA, Long NoncodingSkin NeoplasmsUbiquitin-Protein LigasesAnimalsCell Line, TumorCell MovementCell ProliferationCutaneous Malignant MelanomaEpithelial-Mesenchymal TransitionHumansMiceTranscription FactorsYAP-Signaling ProteinsNeoplasm ProteinsRNA, Long NoncodingTranscription FactorsUbiquitin-Protein LigasesYAP1 protein, humanYAP-Signaling ProteinsImmune-related LncRNAMalignant biological behaviorsPost-transcriptional regulationRNA-binding proteinRNF144A-AS1/TAF15/YAP1 axisSkin cutaneous melanoma

Identifiers

PMID38878223

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.