Evidence map›Paper›PMID 38878202›Full record

Trial reportEuropean journal of nutrition2024

Vitamin D supplementation for cardiometabolic risk markers in pregnant women based on the gestational diabetes mellitus or obesity status : a randomized clinical trial.

Wan-Jun Yin, Peng Wang, Shuang-Shuang Ma, Rui-Xue Tao, Hong-Lin Hu, Xiao-Min Jiang, Ying Zhang, Fang-Biao Tao, Peng Zhu

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07457515 (Analysis of the Transmission of Overweight/Obesity in the Mother-breastmilk-child Triad in Relation to Maternal Cardiometabolic Status and Diet), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07457515 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Analysis of the Transmission of Overweight/Obesity in the Mother-breastmilk-child Triad in Relation to Maternal Cardiometabolic Status and Diet

TypeobservationalSponsorWarsaw University of Life SciencesRan2026 to 2029Enrolled165ConditionsBody Weight, Obesity & Overweight, Human Milk/Breastfeeding, Body Composition
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wan-Jun YinJoint Research Center of Occupational Medicine and Health, Institute of Grand Health, Hefei Comprehensive National Science Center, Anhui University of Science and Technology, Hefei, China.
Peng WangDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.
Shuang-Shuang MaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.
Rui-Xue TaoDepartment of Obstetrics and Gynecology, Hefei First People's Hospital, Hefei, China.
Hong-Lin HuDepartment of endocrinology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Xiao-Min JiangDepartment of Obstetrics and Gynecology, Anhui Province Maternity and Child Health Hospital, Hefei, China.
Ying ZhangDepartment of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University, Hefei, China.
Fang-Biao TaoDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.
Peng ZhuDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China. pengzhu@ahmu.edu.cn.ORCID http://orcid.org/0000-0001-7424-6765

Funding

National Natural Science Foundation of China 82173531
6 · The paper itself

Abstract

purposeWomen with gestational diabetes mellitus (GDM) or obesity are vulnerable to impaired gestational cardiovascular health (CVH) and cardiovascular disease (CVD) in the future. It is unclear if prenatal vitamin D supplementation improves gestational CVH, especially in women at high risk for developing CVD. Our goal was to find out if vitamin D supplementation could protect against gestational CVH, including the women with GDM or obesity.

designWe randomly assigned women with a serum 25(OH)D concentration < 75 nmol/L to receive 1600 IU/d (intervention group) or 400 IU/d (control group) of vitamin D3 for two months at 24-28 weeks' gestation. The primary outcome was gestational CVH marks (lipids, inflammatory cytokines, endothelial function).

resultsThere were 1537 participants divided into the intervention (N = 766) and control groups (N = 771). No baseline differences existed among study groups in CVH markers. At the two-month visit, the intervention group's HDL-C levels (2.01 ± 0.39 VS 1.96 ± 0.39 mmol/L) were significantly higher than those of the control group, while the hs-CRP levels were significantly lower (3.28 ± 2.02 VS 3.64 ± 2.42 mg/L). Subgroup analysis found that HDL-C, TC, hs-CRP, E-Selectin, and SBP were improved in the intervention group among women with GDM or overweight/obesity, and the improvement was not found in women without GDM or overweight/obesity. Vitamin D supplementation significantly decreased the mean triglyceride-glucose index at the two-month visit in women with GDM.

conclusionsVitamin D supplementation at mid-gestation might optimize the gestational CVH status for pregnant women, particularly the women with GDM or obesity, which is advantageous for later-life primary prevention of CVD. CLINICAL

trial registrationThe Chinese Clinical Trial Registry (ChiCTR2100051914, 10/9/2021, Prospective registered, https://www.chictr.org.cn/showproj.aspx?proj=134700 ).

Indexed as

Diabetes, GestationalDietary SupplementsObesityVitamin DAdultBiomarkersCardiometabolic Risk FactorsCardiovascular DiseasesFemaleHumansPregnancyPregnancy ComplicationsBiomarkersVitamin DCardiovascular healthGestational diabetes mellitusObesityPregnant womenVitamin D

Identifiers

PMID38878202

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.