Evidence map›Paper›PMID 38878143›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2024

Abnormal neurovascular control during central and peripheral chemoreceptors stimulation in heart failure patients with preserved ejection fraction.

Yufuko Kataoka, Allan R K Sales, Amanda G Rodrigues, Beatriz R Goes-Santos, Luciene F Azevedo, Raphaela V Groehs, Edna O Silva, Luciana S Santos, Patricia A Oliveira, Camila P Jordão and 7 more

Abstract read
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In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yufuko KataokaFaculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, CEP 05403-904, Brazil.
Allan R K SalesFaculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, CEP 05403-904, Brazil.
Amanda G RodriguesFaculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, CEP 05403-904, Brazil.
Beatriz R Goes-SantosSchool of Physical Education, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Luciene F AzevedoFaculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, CEP 05403-904, Brazil.
Raphaela V GroehsFaculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, CEP 05403-904, Brazil.
Edna O SilvaSchool of Physical Education and Sport, University of São Paulo, São Paulo, Brazil.
Luciana S SantosFaculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, CEP 05403-904, Brazil.
Patricia A OliveiraFaculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, CEP 05403-904, Brazil.
Camila P JordãoFaculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, CEP 05403-904, Brazil.
Ana C M AndradeFaculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, CEP 05403-904, Brazil.
Denise M L LoboPhysiotherapy Unit, Fametro University Center (Unifametro), Fortaleza, Ceará, Brazil.
Eduardo RondonFaculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, CEP 05403-904, Brazil.
Edgar Toschi-DiasPsychology, Development and Public Policy Program, Catholic University of Santos, São Paulo, Brazil.
Maria Janieire N N AlvesFaculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, CEP 05403-904, Brazil.
Dirceu R AlmeidaDivision of Cardiology, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil.
Carlos E NegrãoFaculdade de Medicina, Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 44, Cerqueira César, São Paulo, CEP 05403-904, Brazil. cndnegrao@usp.br.ORCID http://orcid.org/0000-0003-4652-1226

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico #304697/2020-6Conselho Nacional de Desenvolvimento Científico e Tecnológico #307434/2021-4Coordenação de Aperfeiçoamento de Pessoal de Nível Superior #88887.829284/2023-00Fundação de Amparo à Pesquisa do Estado de São Paulo #2013/07607-8Fundação de Amparo à Pesquisa do Estado de São Paulo #2014/11671-6Fundação de Amparo à Pesquisa do Estado de São Paulo #2017/25613-6Fundação de Amparo à Pesquisa do Estado de São Paulo #2020/03375-9Fundação de Amparo à Pesquisa do Estado de São Paulo #2021/03076-4
6 · The paper itself

Abstract

purposeCentral and peripheral chemoreceptors are hypersensitized in patients with heart failure with reduced ejection fraction. Whether this autonomic alteration occurs in patients with heart failure with preserved ejection fraction (HFpEF) remains little known. We test the hypothesis that the central and peripheral chemoreflex control of muscle sympathetic nerve activity (MSNA) is altered in HFpEF.

methodsPatients aged 55-80 years with symptoms of heart failure, body mass index ≤ 35 kg/m

resultsDuring hypoxia, MSNA responses were greater (p < 0.001) and FBF responses were lower in patients with HFpEF (p = 0.006). Likewise, MSNA responses during hypercapnia were higher (p < 0.001) and forearm vascular conductance (FVC) levels were lower (p = 0.030) in patients with HFpEF.

conclusionsPeripheral and central chemoreflex controls of MSNA are hypersensitized in patients with HFpEF, which seems to contribute to the increase in MSNA in these patients. In addition, peripheral and central chemoreceptors stimulation in patients with HFpEF causes muscle vasoconstriction.

Indexed as

Chemoreceptor CellsHeart FailureStroke VolumeAgedAged, 80 and overFemaleHumansMaleMiddle AgedMuscle, SkeletalSympathetic Nervous SystemChemoreceptors stimulationHeart failure with preserved ejection fractionMuscle blood flowSympathetic nerve activity

Identifiers

PMID38878143

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.