Evidence map›Paper›PMID 38878116›Full record

ArticleMolecular neurobiology2025

Hippocampal GPR35 Participates in the Pathogenesis of Cognitive Deficits and Emotional Alterations Induced by Aβ

YuSheng Liang, Yan Yang, Zhi Jie, Xu Kang, Heng Xu, HaiWang Zhang, Xian Wu

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

YuSheng Liang *School of Pharmacy, The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Yan Yang *School of Pharmacy, The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Zhi Jie *School of Pharmacy, The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Xu KangSchool of Pharmacy, The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Heng XuSchool of Pharmacy, The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Medical University, Hefei, 230032, China.
HaiWang ZhangSchool of Pharmacy, The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Medical University, Hefei, 230032, China.
Xian WuSchool of Pharmacy, The Key Laboratory of Major Autoimmune Diseases of Anhui Province, Anhui Medical University, Hefei, 230032, China. wuxian2018@126.com.

Funding

Anhui Medical University School Funding Project 2020xkj012Doctor Foundation of Anhui Medical University 0601086201National undergraduate innovation and entrepreneurship training program 20201036602Natural Science Foundation of Anhui Province 2108085QH385
6 · The paper itself

Abstract

The amyloid-beta (Aβ) aggregation in Alzheimer's disease (AD) triggers neuroinflammation, and neurodegeneration, which lead to cognitive deficits along with other neuropsychiatric symptoms, including depression and anxiety. G protein-coupled receptor 35 (GPR35) is expressed in the brain and is involved in metabolic stresses. However, the role of GPR35 in AD pathogenesis remains unknown. Herein, pharmacological blockade, shRNA-mediated knockdown or knockout of GPR35 was performed to investigate the role and mechanisms of GPR35 in Aβ

Indexed as

Amyloid beta-PeptidesCognitive DysfunctionHippocampusPeptide FragmentsReceptors, G-Protein-CoupledAlzheimer DiseaseAnimalsApoptosisDisease Models, AnimalEmotionsMaleMiceMice, Inbred C57BLMice, TransgenicSignal TransductionAmyloid beta-Peptidesamyloid beta-protein (1-42)GPR35 protein, mousePeptide FragmentsReceptors, G-Protein-CoupledAlzheimer’s diseaseAβ1–42Cognitive impairmentGPR35Neuroinflammation

Identifiers

PMID38878116

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.