ArticleCellular and molecular life sciences : CMLS2024
The novel function of an orphan pheromone receptor reveals the sensory specializations of two potential distinct types of sex pheromones in noctuid moth.
Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Genome-wide identification of olfactory receptor and odorant-binding protein gene families and their roles in Heliothine chemosensory evolution.Insect molecular biology · 2026Article
- Research Progress on Sex Pheromone Receptors in Insects.Insects · 2026Review
- Expanding the sensory horizon: chemosensory receptors beyond traditional olfactory and taste organs in insects.Science China. Life sciences · 2026Review
- SNMPs Function as Molecular Bridges between OBPs and ORs in the Olfactory Recognition of Clostera Retitura (Walker) (Lepidoptera: Notodontidae).Journal of chemical ecology · 2025Article
- Probing the optimal architecture and molecular mechanism of insect odorant receptor heteromeric channels.Communications biology · 2025Article
- A high-quality chromosome-level genome assembly of the oligophagous fruit fly Bactrocera tsuneonis (Diptera: Tephritidae) and insights into its host specificity.GigaScience · 2025Article
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10 authors.
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Abstract
Sex pheromones play crucial role in mating behavior of moths, involving intricate recognition mechanisms. While insect chemical biology has extensively studied type I pheromones, type II pheromones remain largely unexplored. This study focused on Helicoverpa armigera, a representative species of noctuid moth, aiming to reassess its sex pheromone composition. Our research unveiled two previously unidentified candidate type II sex pheromones-3Z,6Z,9Z-21:H and 3Z,6Z,9Z-23:H-in H. armigera. Furthermore, we identified HarmOR11 as an orphan pheromone receptor of 3Z,6Z,9Z-21:H. Through AlphaFold2 structural prediction, molecular docking, and molecular dynamics simulations, we elucidated the structural basis and key residues governing the sensory nuances of both type I and type II pheromone receptors, particularly HarmOR11 and HarmOR13. This study not only reveals the presence and recognition of candidate type II pheromones in a noctuid moth, but also establishes a comprehensive structural framework for PRs, contributing to the understanding of connections between evolutionary adaptations and the emergence of new pheromone types.
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