Evidence map›Paper›PMID 38877716›Full record

Trial reportJDR clinical and translational research2025

Enhancing Intraoral Fluoride Retention in Older Adults: A Randomized Crossover Study.

J Baez-Polan, T E Danciu, D Sweier, C González-Cabezas, M Fontana, L M A Tenuta

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in JDR clinical and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04239872 (Optimizing Fluoride Retention in the Mouth of Older Adults With Distinct Salivary Flow Rates), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04239872 phase1completednot on this map

Optimizing Fluoride Retention in the Mouth of Older Adults With Distinct Salivary Flow Rates

TypeinterventionalSponsorUniversity of MichiganRan2020 to 2021Enrolled20ConditionsHyposalivationArmsFluoride mouthwash, Calcium and fluoride mouthwash
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J Baez-PolanGraduate Program in Restorative Dentistry, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
T E DanciuDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
D SweierDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
C González-CabezasDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.
M FontanaDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID 0000-0003-2357-7534
L M A TenutaDepartment of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI, USA.ORCID 0000-0003-4626-4477

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
NCATS NIH HHS UL1 TR002240
6 · The paper itself

Abstract

introductionPrevious studies have shown that a calcium prerinse can increase intraoral fluoride retention from a fluoride rinse. To explore the potential of this approach to control root caries, we assessed intraoral fluoride bioavailability after a calcium prerinse in older adults with normal to low salivary flow rates.

methodsIn a 2-period crossover trial (NCT04239872), 20 participants (65-80 y old), with low or normal salivary flow rate, rinsed for 1 min with a 0.05% NaF mouth rinse (226 ppm F, F only) or with this rinse immediately after a 1-min rinse with 150 mM calcium lactate (Ca→F). Dental biofilm and saliva samples were collected before and up to 2 h after the rinse(s). Fluoride concentrations in saliva (whole and clarified) and dental biofilm (fluid and solid phases) were blindly determined. Data were statistically analyzed by a mixed-effects model for the effect of treatment, time, and their interaction (

resultsThe Ca→F group resulted in significantly higher fluoride concentrations in all variables analyzed, for almost all of the collection time points. The effect was greater in the biofilm solids and whole saliva (compatible with the formation of calcium fluoride deposits) and still significant (

conclusionThe use of a calcium prerinse before a fluoride rinse was able to prolong intraoral fluoride bioavailability in older adults. KNOWLEDGE TRANSFER STATEMENT: A calcium prerinse increased intraoral fluoride bioavailability in older individuals. This approach could be used to improve root caries control without the need to increase the fluoride concentration in dental products.

Indexed as

BiofilmsFluoridesMouthwashesSalivaAgedAged, 80 and overBiological AvailabilityCariostatic AgentsCross-Over StudiesFemaleHumansMaleSodium FluorideCariostatic AgentsFluoridesMouthwashesSodium Fluoridecalciumdental care for agedmouthwashesroot cariestoothpastesxerostomia

Identifiers

PMID38877716
PMCPMC11653333

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.