ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Patterns of cognitive domain abnormalities enhance discrimination of dementia risk prediction: The ARIC study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Cognitive benefits of hearing intervention vary by risk of cognitive decline: A secondary analysis of the ACHIEVE trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Machine Learning Integration of Eye-Tracking and Cognitive Screening for Detecting Cognitive Impairment.Journal of eye movement research · 2026Article
- Associations of blood biomarkers of glial cell dysfunction and neuronal injury with future cognitive decline and incident dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Machine learning-based LASSO-Cox model for dementia prediction: The role of midlife cardiometabolic, inflammatory, and genetic risk factors in a US cohort.Annals of epidemiology · 2026Article
- Sex differences in the association of vascular risk and APOE Genotype with cognitive decline and dementia: evidence from a U.S. longitudinal study.Lancet regional health. Americas · 2026Article
- Association Between Circadian Rest-Activity Rhythms and Incident Dementia in Older Adults: The Atherosclerosis Risk in Communities Study.Neurology · 2026Article
- Olfaction and Coronary Heart Disease.JAMA otolaryngology-- head & neck surgery · 2026Article
- Novel sleep metrics derived from chest-worn accelerometers are associated with dementia risk: the Atherosclerosis Risk in Communities neurocognitive study.Sleep advances : a journal of the Sleep Research Society · 2026Article
- A novel early screening approach for MCI due to AD based on a "maze" hand-interaction kinetic paradigm.Frontiers in neuroscience · 2026Article
- Ambient air pollution and incident dementia: exploration of relevant exposure windows.Environmental research · 2025Article
- DNA Methylation Signatures of Systemic Inflammation Are Associated With Brain Volume, Cognitive Trajectories, and Long-Term Dementia Risk.Aging cell · 2025Article
- Stroke, Cardiovascular Disease, and Dementia After Hospitalized TIA: The Atherosclerosis Risk in Communities Study.Neurology · 2025Article
- Polypharmacy and Potentially Inappropriate Medications in Adults ≥75 Years of Age by Dementia and Frailty Status: The ARIC Study.Mayo Clinic proceedings · 2025Article
- Traumatic brain injury, changes in plasma amyloid, tau, and neurodegenerative biomarkers, and dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia.Communications medicine · 2025Article
- COVID-19 and Cognitive Change in a Community-Based Cohort.JAMA network open · 2025Article
- Plasma Proteins Associated with the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet and Incident Dementia.The Journal of nutrition · 2025Article
- Association of Body Mass Index in Late Life, and Change from Midlife to Late Life, With Incident Dementia in the ARIC Study Participants.Neurology · 2025Observational
- Lifetime risk and projected burden of dementia.Nature medicine · 2025Article
- Patterns of cognitive domain abnormalities enhance discrimination of dementia risk prediction: The ARIC study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
introductionThe contribution of neuropsychological assessments to risk assessment for incident dementia is underappreciated.
methodsWe analyzed neuropsychological testing results in dementia-free participants in the Atherosclerosis Risk in Communities (ARIC) study. We examined associations of index domain-specific neuropsychological test performance with incident dementia using cumulative incidence curves and Cox proportional hazards models.
resultsAmong 5296 initially dementia-free participants (mean [standard deviation] age of 75.8 [5.1] years; 60.1% women, 22.2% Black) over a median follow-up of 7.9 years, the covariate-adjusted hazard ratio varied substantially depending on the pattern of domain-specific performance and age, in an orderly manner from single domain language abnormalities (lowest risk) to single domain executive or memory abnormalities, to multidomain abnormalities including memory (highest risk). DISCUSSION: By identifying normatively defined cognitive abnormalities by domains based on neuropsychological test performance, there is a conceptually orderly and age-sensitive spectrum of risk for incident dementia that provides valuable information about the likelihood of progression. HIGHLIGHTS: Domain-specific cognitive profiles carry enhanced prognostic value compared to mild cognitive impairment. Single-domain non-amnestic cognitive abnormalities have the most favorable prognosis. Multidomain amnestic abnormalities have the greatest risk for incident dementia. Patterns of domain-specific risks are similar by sex and race.
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