Evidence map›Paper›PMID 38877446›Full record

Trial reportBMC oral health2024

The effect of platelet-rich fibrin (PRF) versus freeze-dried bone allograft (FDBA) used in alveolar ridge preservation on the peri-implant soft and hard tissues: a randomized clinical trial.

Hassan Azangookhiavi, Sareh Habibzadeh, Houyar Zahmatkesh, Ehsan Mellati, Seyed Ali Mosaddad, Yalda Dadpour

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05005377 (Peri-Implant Soft and Hard Tissue Stability After Loading of Implants Following Socket Preservation With Platelet-Rich Fibrin and Freeze-Dried Bone Allograft), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05005377 nacompletednot on this map

Peri-Implant Soft and Hard Tissue Stability After Loading of Implants Following Socket Preservation With Platelet-Rich Fibrin and Freeze-Dried Bone Allograft

TypeinterventionalSponsorTehran University of Medical SciencesRan2016 to 2020Enrolled48ConditionsAlveolar Ridge Augmentation, Bone TransplantationArmsSocket Preservation with Platelet-Rich Fibrin, Socket Preservation with Freeze-Dried Bone Allograft
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hassan AzangookhiaviDepartment of Prosthodontics, School of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
Sareh HabibzadehDepartment of Prosthodontics, School of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
Houyar ZahmatkeshPrivate Practice, Tehran, Iran.
Ehsan MellatiUniversity of Sydney, Sydney, Australia.
Seyed Ali MosaddadDepartment of Research Analytics, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College and Hospitals, Saveetha University, Chennai, India.
Yalda DadpourDepartment of Periodontics, International Campus, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. ydadpour@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe effectiveness of alveolar ridge preservation on bone regeneration and tissue healing has been thoroughly documented in the literature. This study aimed to evaluate the peri-implant soft and hard tissue changes after alveolar ridge preservation using either platelet-rich fibrin (PRF) or freeze-dried bone allograft (FDBA) over a 12-month period following the prosthetic loading of implants.

methodsIn this randomized clinical trial, 40 individuals were recruited for alveolar ridge preservation using (1) FDBA or (2) PRF in incisal/premolar areas. At two follow-up sessions (six- and 12-months post-implant insertion), radiographic imaging and clinical examinations assessed marginal bone loss and soft tissue factors, including gingival recession and bleeding on probing. The differences between study groups were analyzed using Generalized estimating Equations, the Binary logistic regression model, and Cochran's Q test.

resultsThere was a statistically significant difference regarding gingival recession at both follow-up evaluations; values in the PRF group were considerably lower compared to the FDBA group (p < 0.05). The mean values for vertical marginal bone loss and bleeding on probing showed no significant differences between the two study groups (p > 0.05).

conclusionsExcept for gingival recession, applying PRF yielded comparable clinical results to FDBA after one year of implant loading and could be recommended as a potential biomaterial for alveolar ridge preservation following tooth extractions. CLINICAL

trial registrationThe research protocol was registered in the Protocol Registration and Results System on 13/08/2021, available at https://clinicaltrials.gov/ (NCT05005377).

Indexed as

Alveolar Bone LossBone TransplantationFreeze DryingPlatelet-Rich FibrinAdultAllograftsAlveolar Ridge AugmentationFemaleGingival RecessionHumansMaleMiddle AgedAllograftsAlveolar Bone GraftingAlveolar Ridge AugmentationBone substitutesPlatelet-Rich Fibrin

Identifiers

PMID38877446
PMCPMC11179368

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.