ArticleBMC cancer2024
Prognostic value of the Naples prognostic score in patients with intrahepatic cholangiocarcinoma after hepatectomy.
Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic value of the pretreatment Naples prognostic score in gastrointestinal cancer patients: an updated meta-analysis with 28 studies.Systematic reviews · 2025Pooled it
- Prognostic value of the pretreatment Naples prognostic score in patients with colorectal cancer: a systematic review and meta-analysis.Frontiers in oncology · 2024Pooled it
- Prognostic Power of the Naples Score in Non-Small Cell Lung Cancer: Can Inflammation and Nutrition Predict Survival?Journal of clinical medicine · 2025Article
- Associations between naples prognostic score and stroke and mortality among older adults.European journal of medical research · 2025Article
- Impact of the Naples Prognostic Score at admission on long-term prognosis among patients with coronary artery disease.Frontiers in immunology · 2025Article
- A Multicenter Study of Systemic Inflammatory Biomarkers for Prognostic Evaluation in iCCA Patients.Journal of inflammation research · 2025Article
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Authors and funding
16 authors.
Funding
Abstract
backgroundThe Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the prognosis of various malignancies, but there is no report on intrahepatic cholangiocarcinoma (ICC). This study aimed to explore the prognostic value of NPS in patients with ICC.
methodsPatients with ICC after hepatectomy were collected, and divided into three groups. The prognosis factors were determined by Cox regression analysis. Predictive efficacy was evaluated by the time-dependent receiver operating characteristic (ROC) curves.
resultsA total of 174 patients were included (Group 1: 33 (19.0%) patients; Group 2: 83 (47.7%) patients; and Group 3: 58 (33.3%) patients). The baseline characteristics showed the higher the NPS, the higher the proportion of patients with cirrhosis and Child-Pugh B, and more advanced tumors. The Kaplan-Meier curves reflect higher NPS were associated with poor survival. Multivariable analysis showed NPS was an independent risk factor of overall survival (NPS group 2 vs. 1: HR = 1.671, 95% CI: 1.022-3.027, p = 0.009; NPS group 3 vs. 1: HR = 2.208, 95% CI: 1.259-4.780, p = 0.007) and recurrence-free survival (NPS group 2 vs. 1: HR = 1.506, 95% CI: 1.184-3.498, p = 0.010; NPS group 3 vs. 1: HR = 2.141, 95% CI: 2.519-4.087, P = 0.001). The time ROC indicated NPS was superior to other models in predicting prognosis.
conclusionsNPS is a simple and effective tool for predicting the long-term survival of patients with ICC after hepatectomy. Patients with high NPS require close follow-up, and improving NPS may prolong the survival time.
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