Evidence map›Paper›PMID 38877381›Full record

ArticleCardiovascular toxicology2024

Levamisole Impairs Vascular Function by Blocking α-Adrenergic Receptors and Reducing NO Bioavailability in Rabbit Renal Artery.

Sol Guerra-Ojeda, Patricia Marchio, Andrea Suarez, Martin Aldasoro, Soraya L Valles, Patricia Genoves, Jose M Vila, Maria D Mauricio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sol Guerra-Ojeda *Department of Physiology, School of Medicine, University of Valencia, Blasco Ibañez, 15, 46010, Valencia, Spain.
Patricia Marchio *Department of Physiology, School of Medicine, University of Valencia, Blasco Ibañez, 15, 46010, Valencia, Spain.
Andrea SuarezDepartment of Physiology, School of Medicine, University of Valencia, Blasco Ibañez, 15, 46010, Valencia, Spain.
Martin AldasoroDepartment of Physiology, School of Medicine, University of Valencia, Blasco Ibañez, 15, 46010, Valencia, Spain.
Soraya L VallesDepartment of Physiology, School of Medicine, University of Valencia, Blasco Ibañez, 15, 46010, Valencia, Spain.
Patricia GenovesDepartment of Physiology, School of Medicine, University of Valencia, Blasco Ibañez, 15, 46010, Valencia, Spain.
Jose M Vila *Department of Physiology, School of Medicine, University of Valencia, Blasco Ibañez, 15, 46010, Valencia, Spain.
Maria D Mauricio *Department of Physiology, School of Medicine, University of Valencia, Blasco Ibañez, 15, 46010, Valencia, Spain. m.dolores.mauricio@uv.es.

Funding

Ministerio de Universidades Margarita Salas UP2021-044 and MS21-16
6 · The paper itself

Abstract

Levamisole is an anthelmintic drug restricted to veterinary use but is currently detected as the most widely used cocaine cutting agent in European countries. Levamisole-adulterated cocaine has been linked to acute kidney injury, marked by a decrease in glomerular filtration rate, which involves reduced renal blood flow, but data on the alteration of renovascular response produced by levamisole are scarce. Renal arteries were isolated from healthy rabbits and used for isometric tension recording in organ baths and protein analysis. We provide evidence that depending on its concentration, levamisole modulates renovascular tone by acting as a non-selective α-adrenergic receptor blocker and down-regulates α

Indexed as

LevamisoleNitric OxideRenal ArteryVasodilationAdrenergic alpha-1 Receptor AntagonistsAnimalsDose-Response Relationship, DrugMaleNADPH Oxidase 4Nitric Oxide Synthase Type IIIOxidative StressRabbitsReceptors, Adrenergic, alpha-1Superoxide DismutaseSuperoxide Dismutase-1Vasodilator AgentsAdrenergic alpha-1 Receptor AntagonistsLevamisoleNADPH Oxidase 4Nitric OxideNitric Oxide Synthase Type IIIReceptors, Adrenergic, alpha-1Superoxide DismutaseSuperoxide Dismutase-1Vasodilator AgentsEndothelial dysfunctionLevamisoleOxidative stressRenovascular tone

Identifiers

PMID38877381
PMCPMC11300484

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.