Evidence map›Paper›PMID 38877334›Full record

ArticleDigestive diseases and sciences2024

Low Vitamin D Levels in Patients with Symptoms of Gastroparesis: Relationships with Nausea and Vomiting, Gastric Emptying and Gastric Myoelectrical Activity.

Kenneth L Koch, Henry P Parkman, Katherine P Yates, Mark L Van Natta, Madhusudan Grover, Gianrico Farrugia, Thomas L Abell, Richard W McCallum, Irene Sarosiek, Braden Kuo and 4 more

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Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kenneth L KochSection Of Gastroenterology, Wake Forest University, Winston-Salem, NC, USA.
Henry P ParkmanSection of Gastroenterology, Temple University, Philadelphia, PA, USA. henry.parkman@temple.edu.
Katherine P YatesJohns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Mark L Van NattaJohns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Madhusudan GroverMayo Clinic, Rochester, MN, USA.
Gianrico FarrugiaMayo Clinic, Rochester, MN, USA.
Thomas L AbellDigestive and Liver Health, University of Louisville, Louisville, KY, USA.
Richard W McCallumDivision of Gastroenterology, Texas Tech University, El Paso, TX, USA.
Irene SarosiekDivision of Gastroenterology, Texas Tech University, El Paso, TX, USA.
Braden KuoMassachusetts General Hospital, Boston, MA, USA.
Robert J ShulmanChildren's Nutrition Center, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
Laura MirielJohns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
James TonasciaJohns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Pankaj J PasrichaMayo Clinic, Scottsdale, AZ, USA.

Funding

Gastroparesis Consortium Continuation-Data Coordinating CenterU01DK074008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TONASCIA, JAMES A · 2006 to 2015
$17.4M
PGpR2 Year 4 Supplement for the Scientific Data Research Center (SDRC) of the GpCRC 4U24DK074008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI David M Shade · 2017 to 2026
$11.7M
Subtypes of GastroparesisU01DK073974 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Baharak Moshiree · 2006 to 2026
$7.4M
Temple University Gastroparesis Clinical CenterU01DK073975 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI HENRY PAUL PARKMAN · 2006 to 2026
$7.4M
U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis ConsortiumU01DK074007 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Thomas Lyman Abell · 2006 to 2026
$7.0M
Molecular Approaches to Pathogenesis/Therapy in GastropaU01DK073983 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PANKAJ J PASRICHA · 2006 to 2026
$6.8M
The GpCRC Pediatric Gastroparesis Registry 2 (PGpR2): Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants with Symptoms of GastU01DK074035 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Irene Sarosiek · 2008 to 2026
$6.7M
Institute for Clinical and Translational ResearchUL1TR000424 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2012 to 2012
$6.0M
Advancing Clinical Science in Pediatric GastroparesisU01DK112194 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Bruno Pedro Chumpitazi, Geoffrey A Preidis · 2016 to 2026
$5.3M
New England Gastropareis Consortium: Neurobiology of GastroparesisU01DK112193 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Helen Burton Murray, Braden Kuo · 2016 to 2026
$4.8M
NCATS NIH HHS UL1 TR000424NCATS NIH HHS UL1TR000424NIDDK NIH HHS U01 DK073974NIDDK NIH HHS U01DK073974NIDDK NIH HHS U01 DK073975NIDDK NIH HHS U01DK073975NIDDK NIH HHS U01 DK073983NIDDK NIH HHS U01DK073983NIDDK NIH HHS U01 DK074007NIDDK NIH HHS U01DK074007NIDDK NIH HHS U01 DK074008NIDDK NIH HHS U01 DK074035NIDDK NIH HHS U01DK074035NIDDK NIH HHS U01 DK112193NIDDK NIH HHS U01DK112193NIDDK NIH HHS U01DK112194NIDDK NIH HHS U24 DK074008NIDDK NIH HHS U24DK074008
6 · The paper itself

Abstract

Patients with gastroparesis (Gp) often have diets deficient in calories, electrolytes, and vitamins. Vitamin D levels have been reported to be low in some patients with Gp but has not been systematically studied.

aimsTo determine vitamin D levels and relationships among symptoms, gastric emptying and gastric myoelectrical activity (GMA) in patients with symptoms of Gp.

methods25-hydroxy-vitamin D was measured in patients at enrollment in the Gastroparesis Clinical Consortium Registry. Gastroparesis Cardinal Symptoms Index (GCSI), gastric emptying, and GMA before and after water load satiety test (WLST) were measured. GMA, expressed as percentage distribution of activity in normal and dysrhythmic ranges, was recorded using electrogastrography.

resultsOverall, vitamin D levels were low (< 30 ng/ml) in 288 of 513 (56.1%) patients with symptoms of Gp (206 of 376 (54.8%) patients with delayed gastric emptying (Gp) and 82 of 137 (59.9%) patients with symptoms of Gp and normal gastric emptying). Low vitamin D levels were associated with increased nausea and vomiting (P < 0.0001), but not with fullness or bloating subscores. Low vitamin D levels in patients with Gp were associated with greater meal retention at four hours (36% retention) compared with Gp patients with normal vitamin D levels (31% retention; P = 0.05). Low vitamin D in patients with normal gastric emptying was associated with decreased normal 3 cpm GMA before (P = 0.001) and increased tachygastria after WLST (P = 0.01).

conclusionsLow vitamin D levels are present in half the patients with symptoms of gastroparesis and are associated with nausea and vomiting and gastric neuromuscular dysfunction.

Indexed as

Gastric EmptyingGastroparesisNauseaVitamin DVomitingAdultFemaleHumansMaleMiddle AgedStomachVitamin D Deficiency25-hydroxyvitamin DVitamin DFunctional dyspepsiaGastric dysrhythmiasGastroparesisNausea and vomitingVitamin D deficiency

Identifiers

PMID38877334
PMCPMC11341680

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.