Evidence map›Paper›PMID 38877224›Full record

ArticleNature microbiology2024

Chromosomal integration of the pSOL1 megaplasmid of Clostridium acetobutylicum for continuous and stable advanced biofuels production.

Muhammad Ehsaan, Minyeong Yoo, Wouter Kuit, Céline Foulquier, Philippe Soucaille, Nigel P Minton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Micro-engineering the future.Nature microbiology · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Muhammad Ehsaan *BBSRC/EPSRC Synthetic Biology Research Centre, School of Life Sciences, Biodiscovery Institute, University of Nottingham, Nottingham, UK.
Minyeong Yoo *BBSRC/EPSRC Synthetic Biology Research Centre, School of Life Sciences, Biodiscovery Institute, University of Nottingham, Nottingham, UK.
Wouter KuitBBSRC/EPSRC Synthetic Biology Research Centre, School of Life Sciences, Biodiscovery Institute, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0009-0005-1105-472X
Céline FoulquierTBI, Université de Toulouse, CNRS, INRAE, INSA, Toulouse, France.
Philippe SoucailleBBSRC/EPSRC Synthetic Biology Research Centre, School of Life Sciences, Biodiscovery Institute, University of Nottingham, Nottingham, UK. soucaille@insa-toulouse.fr.ORCID http://orcid.org/0000-0002-1724-7136
Nigel P MintonBBSRC/EPSRC Synthetic Biology Research Centre, School of Life Sciences, Biodiscovery Institute, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-9277-1261

Funding

Innovate UK BB/S011951/1RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/S011951/1
6 · The paper itself

Abstract

Biofuel production by Clostridium acetobutylicum is compromised by strain degeneration due to loss of its pSOL1 megaplasmid. Here we used engineering biology to stably integrate pSOL1 into the chromosome together with a synthetic isopropanol pathway. In a membrane bioreactor continuously fed with glucose mineral medium, the final strain produced advanced biofuels, n-butanol and isopropanol, at high yield (0.31 g g

Indexed as

1-Butanol2-PropanolBiofuelsBioreactorsClostridium acetobutylicumMetabolic EngineeringPlasmidsChromosomes, BacterialFermentationGlucose1-Butanol2-PropanolBiofuelsGlucose

Identifiers

PMID38877224
PMCPMC11222136

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.