Evidence map›Paper›PMID 38877164›Full record

ArticleCancer gene therapy2024

ScRNA-seq revealed the tumor microenvironment heterogeneity related to the occurrence and metastasis in upper urinary tract urothelial carcinoma.

Shiyong Xin, Yanwei Zhang, Zhenhua Zhang, Ziyao Li, Xianchao Sun, Xiang Liu, Liang Jin, Weiyi Li, Chaozhi Tang, Wangli Mei and 10 more

Abstract read
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In one paragraph

Article in Cancer gene therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Shiyong Xin *Department of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.ORCID 0009-0001-2760-8580
Yanwei Zhang *Department of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Zhenhua Zhang *School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Ziyao LiDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Xianchao SunDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Xiang LiuDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Liang JinDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Weiyi LiDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Chaozhi TangDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Wangli MeiDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Qiong CaoDepartment of Pathology, The Third Affiliated Hospital of Henan University of Science and Technology, Luoyang, 471003, China.
Haojie WangDepartment of Central Laboratory, Zhengzhou University, Luoyang Central Hospital, Luoyang, 471003, China.
Zhihao WeiDepartment of Pathology, Yiluo Hospital of Luoyang, The Teaching Hospital of Henan University of Science and Technology, Luoyang, China.
Zhen ZhouDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Rongbing LiDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Xiaofei WenDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Guosheng YangDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China.
Weihua ChenDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. drchenweihua@126.com.ORCID 0000-0001-8014-0705
Junhua ZhengDepartment of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. zhengjh0471@sina.com.
Lin YeDepartment of Urology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. ericyelin@tongji.edu.cn.ORCID 0000-0002-3304-4558

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81672549National Natural Science Foundation of China (National Science Foundation of China) 81972409
6 · The paper itself

Abstract

Metastasis is the greatest clinical challenge for UTUCs, which may have distinct molecular and cellular characteristics from earlier cancers. Herein, we provide single-cell transcriptome profiles of UTUC para cancer normal tissue, primary tumor lesions, and lymphatic metastases to explore possible mechanisms associated with UTUC occurrence and metastasis. From 28,315 cells obtained from normal and tumor tissues of 3 high-grade UTUC patients, we revealed the origin of UTUC tumor cells and the homology between metastatic and primary tumor cells. Unlike the immunomicroenvironment suppression of other tumors, we found no immunosuppression in the tumor microenvironment of UTUC. Moreover, it is imperative to note that stromal cells are pivotal in the advancement of UTUC. This comprehensive single-cell exploration enhances our comprehension of the molecular and cellular dynamics of metastatic UTUCs and discloses promising diagnostic and therapeutic targets in cancer-microenvironment interactions.

Indexed as

Neoplasm MetastasisTumor MicroenvironmentUrologic NeoplasmsCell-Free Nucleic AcidsFemaleHumansMaleRNA-SeqSingle-Cell Gene Expression AnalysisCell-Free Nucleic Acids

Identifiers

PMID38877164

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.