ArticleArchives of toxicology2024
Time for CHANGE: system-level interventions for bringing forward the date of effective use of NAMs in regulatory toxicology.
Abstract readEditorial
In one paragraph
Article in Archives of toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Computational integration of in vivo single cell and in vitro bulk transcriptomics across 236 human and mouse datasets differentiates physiological versus non-physiological hepatic cell lines for hepatotoxicity screening.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Modelling the regulatory toxicology system to promote the effective use of new approach methodologies: a system thinking approach.NAM journal · 2026Article
- Advancing chemical mixture toxicity assessment using advanced in vitro NAMs: current status and future perspectives.Frontiers in toxicology · 2026Review
- From vivarium to NAM-centred laboratory: A practical framework for managing infrastructure, expertise and organisational transition.NAM journal · 2026Article
- Evidence-based AI: from trailblazer to trustblazer?Frontiers in artificial intelligence · 2026Article
- Preparing for CHANGE: How systems thinking supports an effective transition from animal studies to NAMs.NAM journal · 2026Article
- Exploring experiences of the regulatory toxicology system: system-level promoters and inhibitors of new approach methodologies.Archives of toxicology · 2025Article
- Advances in Cytotoxicity Testing: From In Vitro Assays to In Silico Models.International journal of molecular sciences · 2025Review
- EcoToxChip provides insights into pathway perturbation upon chlorantraniliprole exposure to larval fathead minnow.Aquatic toxicology (Amsterdam, Netherlands) · 2025Article
- Improving how we use workshops when solving complex research problems: reflections from the CHANGE project.Archives of toxicology · 2025Article
- Animal-free safety assessment of chemicals: an innovation system perspective.Archives of toxicology · 2025Review
- A sociological perspective on the challenges of displacing animal research within academia: the contribution of Bourdieu.NAM journal · 2025Article
- CompSafeNano project: NanoInformatics approaches for safe-by-design nanomaterials.Computational and structural biotechnology journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors.
Gro H MathisenNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway. gro.haarklou.mathisen@vkm.no.ORCID http://orcid.org/0000-0003-3824-4898
Angela BearthNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
Lowenna B JonesNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-8623-1218
Sebastian HoffmannEvidence-Based Toxicology Collaboration (EBTC), Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3214-7678
Gunn E VistNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.
Heather M AmesNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0001-8509-7160
Trine HusøyNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-2827-7111
Camilla SvendsenNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-3216-0469
Katya TsaiounEvidence-Based Toxicology Collaboration (EBTC), Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.
Takao AshikagaDivision of Genome Safety Science/JaCVAM, Center for Biological Safety Research (CBSR), National Institute of Health Sciences (NIHS), Kawasaki, Japan.
Denise BlochDepartment of Pesticides Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.ORCID http://orcid.org/0000-0002-1222-9668
Aleksandra CavoskiBirmingham Law School, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0003-0845-3170
Weihsueh A ChiuDepartment of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Holly G DaviesDepartment of Health, Washington State, Tumwater, WA, USA.ORCID http://orcid.org/0000-0002-3711-0604
Arianna GiustiCosmetics Europe, Avenue Herrmann-Debroux 40, 1160, Auderghem, Belgium.ORCID http://orcid.org/0000-0002-7460-3336
Thomas HartungCenter for Alternatives to Animal Testing (CAAT), Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1359-7689
Yoko HirabayashiCenter for Biological Safety Research (CBSR), National Institute of Health Sciences (NIHS), Kawasaki, Japan.
Helena T HogbergNational Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0001-8034-6818
Rashmi JoglekarDepartment of Obstetrics, Gynecology and Reproductive Sciences, Program On Reproductive Health and the Environment, University of California, San Francisco, USA.ORCID http://orcid.org/0000-0002-9912-6628
Hajime KojimaDivision of Food Additives, National Institute of Health Sciences (NIHS), Kawasaki, Japan.
Kannan KrishnanAir and Site Assessment and Climate Indicators Branch, Division of Scientific Programs, Office of Environmental Health Hazard Assessment, 1001 I Street, Sacramento, CA, USA.ORCID http://orcid.org/0000-0002-0247-9612
Seok KwonDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119077, Singapore.ORCID http://orcid.org/0009-0004-4295-9735
Olivia J OsborneChemical Risk Assessment Team, Science, Evidence and Research Division, Food Standards Agency, Petty France, Westminster, London, SW1H 9EX, UK.ORCID http://orcid.org/0009-0008-6021-8358
Erwin Roggen3Rs Management and Consulting ApS, Lyngby, Denmark.ORCID http://orcid.org/0000-0002-9371-8390
Andrew A RooneyDivision of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-1756-5185
Christophe RousselleFrench Agency for Food, Environmental and Occupational Health and Safety (ANSES), 94701, Maisons-Alfort, France.
Jennifer B SassNatural Resources Defense Council, Washington, DC, USA.ORCID http://orcid.org/0000-0003-1279-9510
Ovnair SepaiUK Health Security Agency, London, SE1 8UG, UK.ORCID http://orcid.org/0000-0003-3577-3313
Ulla SimanainenEuropean Chemicals Agency, Helsinki, Finland.ORCID http://orcid.org/0009-0008-7951-3840
Kristina A ThayerCenter for Public Health and Environmental Assessment, Chemical and Pollutant Assessment Division (CPAD), U.S. EPA, Durham, NC, USA.ORCID http://orcid.org/0000-0002-3616-618X
Weida TongNational Center for Toxicological Research of US Food and Drug Administration, Jefferson, AR, USA.
Daniele WikoffToxStrategies, Asheville, NC, USA.ORCID http://orcid.org/0000-0003-0785-161X
Fred WrightDepartments of Statistics and Biological Sciences and Bioinformatics Research Center, North Carolina State University, Raleigh, NC, USA.ORCID http://orcid.org/0000-0002-8238-6626
Paul WhaleyNorwegian Scientific Committee for Food and Environment, Norwegian Institute of Public Health, Oslo, Norway. paul@whaleyresearch.uk.ORCID http://orcid.org/0000-0003-4021-0785
Funding
Single cell, multi-parametric high throughput platform to classify endocrine disruptor potential of mixturesP42ES027704 · NIEHS · TEXAS A&M UNIVERSITY · PI Weihsueh A Chiu · 2017 to 2026
$21.2MScientific Cyberinfrastructure Research ProgramZIAES103385 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WALKER, VICKIE · 2022 to 2025
$17.4MTexas A&M Center for Environmental Health Research (TiCER)P30ES029067 · NIEHS · TEXAS A&M UNIVERSITY · PI Galen Newman · 2019 to 2026
$13.0MConsumer Products and Therapeutics Research ProgramZIAES103379 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI TAYLOR, KYLA · 2022 to 2025
$9.9MIntramural NIH HHS ZIA ES103379NIEHS NIH HHS P30 ES029067NIEHS NIH HHS P42 ES027704
Abstract
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