Evidence map›Paper›PMID 38877153›Full record

ArticleScientific reports2024

Environmental exposures to organophosphorus flame retardants in early pregnancy and risks of gestational diabetes mellitus: a nested case-control study.

Qi Lang, Jiali Sun, Xiangyuan Yu, Shudan Wei, Jinyan Wei, Min Zhang, Chaochao Zhao, Jun Zhang, Dingyuan Zeng, Bo Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qi Lang *Clinical Laboratory Center, First Affiliated Hospital of Guilin Medical University, 109 Ring City North Second Road, Guilin, 541004, Guangxi, China.
Jiali Sun *Guangxi Key Laboratory of Environmental Exposomics and Entire LifeCourse Health, Guangxi Health Commission Key Laboratory of Entire LifeCourse Health and Care, School of Public Health, Guilin Medical University, 1 Zhiyuan Road, Guilin, 541199, Guangxi, China.
Xiangyuan YuGuangxi Key Laboratory of Environmental Exposomics and Entire LifeCourse Health, Guangxi Health Commission Key Laboratory of Entire LifeCourse Health and Care, School of Public Health, Guilin Medical University, 1 Zhiyuan Road, Guilin, 541199, Guangxi, China.
Shudan WeiGuangxi Key Laboratory of Environmental Exposomics and Entire LifeCourse Health, Guangxi Health Commission Key Laboratory of Entire LifeCourse Health and Care, School of Public Health, Guilin Medical University, 1 Zhiyuan Road, Guilin, 541199, Guangxi, China.
Jinyan WeiGuangxi Key Laboratory of Environmental Exposomics and Entire LifeCourse Health, Guangxi Health Commission Key Laboratory of Entire LifeCourse Health and Care, School of Public Health, Guilin Medical University, 1 Zhiyuan Road, Guilin, 541199, Guangxi, China.
Min ZhangGuangxi Key Laboratory of Environmental Exposomics and Entire LifeCourse Health, Guangxi Health Commission Key Laboratory of Entire LifeCourse Health and Care, School of Public Health, Guilin Medical University, 1 Zhiyuan Road, Guilin, 541199, Guangxi, China.
Chaochao ZhaoGuangxi Key Laboratory of Environmental Exposomics and Entire LifeCourse Health, Guangxi Health Commission Key Laboratory of Entire LifeCourse Health and Care, School of Public Health, Guilin Medical University, 1 Zhiyuan Road, Guilin, 541199, Guangxi, China.
Jun ZhangMinistry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital, Shanghai JiaoTong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.
Dingyuan ZengGuangxi Health Commission Key Laboratory of Birth Cohort Study in Pregnant Women With Advanced Age, Liuzhou Maternity and Child Healthcare Hospital, 50 Yingshan Street, Liuzhou, 545001, Guangxi, China.
Bo HuangGuangxi Key Laboratory of Environmental Exposomics and Entire LifeCourse Health, Guangxi Health Commission Key Laboratory of Entire LifeCourse Health and Care, School of Public Health, Guilin Medical University, 1 Zhiyuan Road, Guilin, 541199, Guangxi, China. Bo.Huang@glmc.edu.cn.

Funding

National Natural Science Foundation of China 81760614The Key Research and Development Program of Guangxi 2018AB62004
6 · The paper itself

Abstract

OPFRs are emerging environmental pollutants with reproductive and endocrine toxicity. This study aimed to examine the association between environmental exposure to OPFRs during early pregnancy and GDM. This nested case-control study was based on a birth cohort that was constructed at a maternal and child health hospital, including 74 cases of GDM among 512 pregnant women. The OPFRs, including TBP, TBEP, TCEP, TDCPP, TMCP, TOCP, and TPHP during 10-14 weeks of pregnancy were determined using GC-MS. The association between the OPFRs and GDM was assessed using WQS and BKMR models. The levels of OPFRs were significantly elevated in GDM patients (60) compared with the controls (90). The WQS analysis showed that mixtures of the OPFRs were significantly associated with GDM (OR 1.370, 95% CI 1.036-1.810, P = 0.027), and TBP, TPHP, and TMCP were the major contributors to the mixed exposure effect. In the BKMR model, individual exposure to TBP, TPHP, and TMCP, and the interaction of TMCP with TBP and TPHP were significantly associated with GDM. Environmental exposure to OPFRs is positively associated with GDM. These findings provide evidence for the adverse effects of OPFR exposure on the health of pregnant women.

Indexed as

Diabetes, GestationalEnvironmental ExposureFlame RetardantsAdultCase-Control StudiesEnvironmental PollutantsFemaleHumansMaternal ExposureOrganophosphorus CompoundsPregnancyPregnancy Trimester, FirstRisk FactorsEnvironmental PollutantsFlame RetardantsOrganophosphorus CompoundsBayesian kernel machine regressionGestational diabetes mellitusNested case–control studyOrganophosphorus flame retardantsWeighted quantile regression

Identifiers

PMID38877153
PMCPMC11178875

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.