ArticleScientific reports2024
The effect of body weight on the knee joint biomechanics based on subject-specific finite element-musculoskeletal approach.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Obesity-Associated Osteoarthritis: Mechanical-Metabolic Pathogenesis, Obesity Memory and Dual-Target Therapy.Current obesity reports · 2026Review
- Radiographic Changes in Patellar Height Following Rapid Weight Loss After Sleeve Gastrectomy: A Retrospective Observational Study.Journal of clinical medicine · 2026Article
- Pathological mechanisms of osteoarthritis in the network of geriatric comorbidities: Emerging insights from organs-crosstalk.Journal of orthopaedic translation · 2026Review
- Kinesiophobia and knee biomechanical characteristics in patients with postoperative tibial plateau fractures across body mass index categories: a cross-sectional mediation analysis.Journal of orthopaedic surgery and research · 2026Article
- Predictive Neuromechanical Simulation Explains Gait Biomechanics in Obesity.bioRxiv : the preprint server for biology · 2026Article
- A novel integrative multi-scale framework of inflammation and mechanical loading in knee osteoarthritis.Biomechanics and modeling in mechanobiology · 2026Article
- Five-year outcomes of medial open-wedge high tibial osteotomy with lateral supplemental lag screw in patients with obesity.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2026Article
- An Analysis of Hip and Knee Joint Movement Characteristics in Overweight Individuals During Sit-to-Stand Transfers-Based on Statistical Parametric Mapping: An Exploratory Study.Life (Basel, Switzerland) · 2026Article
- Obesity is linked to impaired sensorimotor synchronization during walking but not tapping.Scientific reports · 2026Article
- Load-carrying biomechanics in children: programed exercise enhances postural resilience and reduces plantar pressure under backpack load.Frontiers in public health · 2026Article
- Elevated Contact Stresses Compromise Activity-Mediated Cartilage Rehydration but not Lubrication.Annals of biomedical engineering · 2025Article
- What determines gait speed in community-living older adults? A relative weight analysis.European geriatric medicine · 2025Article
- Challenges in Combining EMG, Joint Moments, and GRF from Marker-Less Video-Based Motion Capture Systems.Bioengineering (Basel, Switzerland) · 2025Review
- Development of a spinopelvic complex finite element model for quantitative analysis of the biomechanical response of patients with degenerative spondylolisthesis.Medical & biological engineering & computing · 2025Article
- Global, regional, and national burden of knee osteoarthritis attributable to high BMI: a systematic analysis from 1990 to 2021 and projections to 2050.Frontiers in public health · 2025Article
- On the consequences of intra-operative release versus over-tensioning of the posterior cruciate ligament in total knee arthroplasty.Journal of the Royal Society, Interface · 2024Article
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Authors and funding
4 authors.
Funding
Abstract
Knee osteoarthritis (OA) and obesity are major public health concerns that are closely intertwined. This intimate relationship was documented by considering obesity as the most significant preventable risk factor associated with knee OA. To date, however, the effects of obesity on the knee joint's passive-active structure and cartilage loading have been inconclusive. Hence, this study investigates the intricate relationship between obesity and knee OA, centering on the biomechanical changes in knee joint active and passive reactions during the stance phase of gait. Using a subject-specific musculoskeletal and finite element approach, muscle forces, ligament stresses, and articular cartilage contact stresses were analyzed among 60 individuals with different body mass indices (BMI) classified under healthy weight, overweight, and obese categories. Our predicted results showed that obesity significantly influenced knee joint mechanical reaction, increasing muscle activations, ligament loading, and articular cartilage contact stresses, particularly during key instances of the gait cycle-first and second peak loading instances. The study underscores the critical role of excessive body weight in exacerbating knee joint stress distribution and cartilage damage. Hence, the insights gained provide a valuable biomechanical perspective on the interaction between body weight and knee joint health, offering a clinical utility in assessing the risks associated with obesity and knee OA.
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