Evidence map›Paper›PMID 38877069›Full record

ArticleScientific reports2024

Intraluminal oxygen can keep small bowel mucosa intact in a segmental ischemia model.

Guido Trentadue, Peter B F Mensink, Claudius Kruse, Bernward Reszel, Gursah Kats-Ugurlu, Tjasso Blokzijl, Jan Willem Haveman, Klaas Nico Faber, Gerard Dijkstra, Uvo M Hölscher and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guido Trentadue *Department of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ, Groningen, The Netherlands. g.trentadue@umcg.nl.
Peter B F Mensink *Department of Internal Medicine and Gastroenterology, Medisch Spectrum Twente, Enschede, The Netherlands.
Claudius KruseDepartment of Anaesthesiology, University Hospital Muenster, Muenster, Germany.
Bernward ReszelCERES GmbH, Clinical Evaluation and Research, Lörrach, Germany.
Gursah Kats-UgurluDepartment of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Tjasso BlokzijlDepartment of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jan Willem HavemanDepartment of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Klaas Nico FaberDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ, Groningen, The Netherlands.
Gerard DijkstraDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713GZ, Groningen, The Netherlands.
Uvo M HölscherMünster University of Applied Sciences, Steinfurt, Germany.
Jeroen J KolkmanDepartment of Internal Medicine and Gastroenterology, Medisch Spectrum Twente, Enschede, The Netherlands.
Gisbert KnichwitzDepartment of Anaesthesiology, University Hospital Muenster, Muenster, Germany.

Funding

Interreg IIIA, European Union Euregio-project 2-EUR-II-2=15
6 · The paper itself

Abstract

Intestinal preservation for transplantation is accompanied by hypoperfusion with long periods of ischemia with total blood cessation and absolute withdrawal of oxygen leading to structural damage. The application of intraluminal oxygen has been successfully tested in small-animal series during storage and transport of the organ but have been so far clinically unrelatable. In this study, we tested whether a simple and clinically approachable method of intraluminal oxygen application could prevent ischemic damage in a large animal model, during warm ischemia time. We utilised a local no-flow ischemia model of the small intestine in pigs. A low-flow and high-pressure intraluminal oxygen deliverance system was applied in 6 pigs and 6 pigs served as a control group. Mucosal histopathology, hypoxia and barrier markers were evaluated after two hours of no-flow conditions, in both treatment and sham groups, and in healthy tissue. Macro- and microscopically, the luminal oxygen delivered treatment group showed preserved small bowel's appearance, viability, and mucosal integrity. A gradual deterioration of histopathology and barrier markers and increase in hypoxia-inducible factor 1-α expression towards the sites most distant from the oxygen application was observed. Intraluminal low-flow, high oxygen delivery can preserve the intestinal mucosa during total ischemia of the small intestine. This finding can be incorporated in methods to overcome small bowel ischemia and improve intestinal preservation for transplantation.

Indexed as

Intestinal MucosaIntestine, SmallIschemiaOxygenAnimalsDisease Models, AnimalHypoxia-Inducible Factor 1, alpha SubunitOrgan PreservationSwineHypoxia-Inducible Factor 1, alpha SubunitOxygenAnimal disease modelsIntestinal MucosaIntestinal transplantationIschemiaOxygenPreservationSmall intestine

Identifiers

PMID38877069
PMCPMC11178904

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.