Evidence map›Paper›PMID 38877050›Full record

ArticleScientific reports2024

Implantable photonic neural probes with out-of-plane focusing grating emitters.

Tianyuan Xue, Andrei Stalmashonak, Fu-Der Chen, Peisheng Ding, Xianshu Luo, Hongyao Chua, Guo-Qiang Lo, Wesley D Sacher, Joyce K S Poon

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tianyuan XueDepartment of Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Weinberg 2, Halle, 06120, Germany. xuetiany@mail.utoronto.ca.
Andrei StalmashonakDepartment of Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Weinberg 2, Halle, 06120, Germany.
Fu-Der ChenDepartment of Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Weinberg 2, Halle, 06120, Germany.
Peisheng DingDepartment of Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Weinberg 2, Halle, 06120, Germany.
Xianshu LuoAdvanced Micro Foundry Pte. Ltd., 11 Science Park Road, Singapore, 117685, Singapore.
Hongyao ChuaAdvanced Micro Foundry Pte. Ltd., 11 Science Park Road, Singapore, 117685, Singapore.
Guo-Qiang LoAdvanced Micro Foundry Pte. Ltd., 11 Science Park Road, Singapore, 117685, Singapore.
Wesley D SacherDepartment of Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Weinberg 2, Halle, 06120, Germany.
Joyce K S PoonDepartment of Nanophotonics, Integration, and Neural Technology, Max Planck Institute of Microstructure Physics, Weinberg 2, Halle, 06120, Germany. joyce.poon@mpi-halle.mpg.de.

Funding

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada) RGPIN-2018-06491
6 · The paper itself

Abstract

We have designed, fabricated, and characterized implantable silicon neural probes with nanophotonic grating emitters that focus the emitted light at a specified distance above the surface of the probe for spatially precise optogenetic targeting of neurons. Using the holographic principle, we designed gratings for wavelengths of 488 and 594 nm, targeting the excitation spectra of the optogenetic actuators Channelrhodopsin-2 and Chrimson, respectively. The measured optical emission pattern of these emitters in non-scattering medium and tissue matched well with simulations. To our knowledge, this is the first report of focused spots with the size scale of a neuron soma in brain tissue formed from implantable neural probes.

Indexed as

NeuronsOptogeneticsPhotonsAnimalsProstheses and ImplantsSiliconSilicon

Identifiers

PMID38877050
PMCPMC11178810

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.