Evidence map›Paper›PMID 38877008›Full record

ArticleNPJ vaccines2024

Association between antibody responses post-vaccination and severe COVID-19 outcomes in Scotland.

Calum Macdonald, Norah Palmateer, Andrew McAuley, Laura Lindsay, Taimoor Hasan, Safraj Shahul Hameed, Elliot Hall, Karen Jeffrey, Zoë Grange, Petros Gousias and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Calum Macdonald *Usher Institute, University of Edinburgh, Teviot Pl, EH8 9AG, Edinburgh, UK. calum.macdonald@hdruk.ac.uk.ORCID http://orcid.org/0000-0001-7857-9188
Norah Palmateer *School of Health and Life Sciences, Glasgow Caledonian University, Cowcaddens, Road, Glasgow, G4 0BA, UK. norah.palmateer@phs.scot.ORCID http://orcid.org/0000-0003-4493-0173
Andrew McAuleySchool of Health and Life Sciences, Glasgow Caledonian University, Cowcaddens, Road, Glasgow, G4 0BA, UK.
Laura LindsayPublic Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.ORCID http://orcid.org/0000-0002-0512-1640
Taimoor HasanPublic Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.ORCID http://orcid.org/0000-0003-3607-3490
Safraj Shahul HameedPublic Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.ORCID http://orcid.org/0000-0001-5475-1318
Elliot HallPublic Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.
Karen JeffreyUsher Institute, University of Edinburgh, Teviot Pl, EH8 9AG, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0061-6089
Zoë GrangePublic Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.
Petros GousiasPublic Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.
Sally MavinScottish Microbiology Reference Laboratory, Raigmore Hospital, Old Perth Road, Inverness, IV2 3UJ, UK.
Lisa JarvisScottish National Blood Transfusion Service, Jack Copland Centre, 52 Research Avenue North, EH14 4BE, Edinburgh, UK.
J Claire CameronPublic Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.ORCID http://orcid.org/0000-0001-5263-3086
Luke DainesUsher Institute, University of Edinburgh, Teviot Pl, EH8 9AG, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0564-4000
Holly TibbleUsher Institute, University of Edinburgh, Teviot Pl, EH8 9AG, Edinburgh, UK.
Colin R SimpsonSchool of Health, Wellington Faculty of Health, Victoria University of Wellington, PO Box 600, Wellington, 6140, Wellington, New Zealand.ORCID http://orcid.org/0000-0002-5194-8083
Colin McCowanSchool of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, UK.ORCID http://orcid.org/0000-0002-9466-833X
Srinivasa Vittal KatikireddiPublic Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.ORCID http://orcid.org/0000-0001-6593-9092
Igor RudanUsher Institute, University of Edinburgh, Teviot Pl, EH8 9AG, Edinburgh, UK.
Adeniyi Francis FagbamigbeInstitute of Applied Health Sciences, University of Aberdeen, Polwarth Building, Foresterhill Rd, AB25 2ZD, Aberdeen, UK.
Lewis RitchieCentre of Academic Primary Care, University of Aberdeen, Polwarth Building, Foresterhill Rd, AB25 2ZD, Aberdeen, UK.
Ben SwallowSchool of Mathematics and Statistics, University of St Andrews, KY16 9SS, St Andrews, UK.ORCID http://orcid.org/0000-0002-0227-2160
Paul MossInstitute of Immunology and Immunotherapy, University of Birmingham, Cancer Sciences Building, Edgbaston, B15 2TT, Birmingham, UK.ORCID http://orcid.org/0000-0002-6895-1967
Chris RobertsonPublic Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.ORCID http://orcid.org/0000-0001-6848-5241
Aziz SheikhUsher Institute, University of Edinburgh, Teviot Pl, EH8 9AG, Edinburgh, UK.ORCID http://orcid.org/0000-0001-7022-3056
Josie MurrayPublic Health Scotland, Meridian Court, 5 Cadogan Street, G2 6QE, Glasgow, UK.ORCID http://orcid.org/0000-0002-1511-7944

Funding

Medical Research Council MC_UU_00022/2RCUK | Medical Research Council (MRC) MC_PC_19075
6 · The paper itself

Abstract

Several population-level studies have described individual clinical risk factors associated with suboptimal antibody responses following COVID-19 vaccination, but none have examined multimorbidity. Others have shown that suboptimal post-vaccination responses offer reduced protection to subsequent SARS-CoV-2 infection; however, the level of protection from COVID-19 hospitalisation/death remains unconfirmed. We use national Scottish datasets to investigate the association between multimorbidity and testing antibody-negative, examining the correlation between antibody levels and subsequent COVID-19 hospitalisation/death among double-vaccinated individuals. We found that individuals with multimorbidity ( ≥ five conditions) were more likely to test antibody-negative post-vaccination and 13.37 [6.05-29.53] times more likely to be hospitalised/die from COVID-19 than individuals without conditions. We also show a dose-dependent association between post-vaccination antibody levels and COVID-19 hospitalisation or death, with those with undetectable antibody levels at a significantly higher risk (HR 9.21 [95% CI 4.63-18.29]) of these serious outcomes compared to those with high antibody levels.

Identifiers

PMID38877008
PMCPMC11178861

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.