Evidence map›Paper›PMID 38876946›Full record

ReviewJournal of Ayurveda and integrative medicine

Assessing effects of Cannabis on various neuropathologies: A systematic review.

Suhrud Pathak, Jeyaram Bharathi Jeyabalan, Keyi Liu, Preston Cook, Bennett Lange, Shannon Kim, Rishi Nadar, Kiersten Ward, Courtney S Watts Alexander, Ashwani Kumar and 4 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Suhrud PathakHarrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA.
Jeyaram Bharathi JeyabalanHarrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA; Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Nilgiris, Ooty, Tamil Nadu, 643 001, India.
Keyi LiuHarrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA.
Preston CookHarrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA.
Bennett LangeHarrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA.
Shannon KimHarrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA.
Rishi NadarHarrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA.
Kiersten WardHarrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA.
Courtney S Watts AlexanderHarrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA.
Ashwani KumarPatanjali Herbal Research Department, Patanjali Research Foundation, Haridwar, 249405, India.
Kamal DuaDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, Australia; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW, Australia.
Timothy MooreHarrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA.
Jeyabalan GovindasamyAlwar Pharmacy College, Alwar, Rajasthan, 301030, India. Electronic address: Jeyabalan2001@gmail.com.
Muralikrishnan DhanasekaranHarrison College of Pharmacy, Auburn University, Auburn, AL, 36849, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural bioactives possess a wide range of chemical structures that can exert a plethora of pharmacological and toxicological actions, resulting in neuroprotection or neurotoxicity. These pharmacodynamic properties can positively or negatively impact human and animal global healthcare. Remarkably, Ayurvedic botanical Cannabis has been used worldwide by different ethnicities and religions for spiritual, commercial, recreational, nutraceutical, cosmeceutical, and medicinal purposes for centuries. Cannabis-based congeners have been approved by the United States of America's (USA) Food & Drug Administration (FDA) and other global law agencies for various therapeutic purposes. Surprisingly, the strict laws associated with possessing cannabis products have been mitigated in multiple states in the USA and across the globe for recreational use. This has consequently led to a radical escalation of exposure to cannabis-related substances of abuse. However, there is a lacuna in the literature on the acute and chronic effects of Cannabis and its congeners on various neuropathologies. Moreover, in the post-COVID era, there has been a drastic increase in the incidence and prevalence of numerous neuropathologies, leading to increased morbidity and mortality. There is an impending necessity for a safe, economically viable, multipotent, natural bioactive to prevent and treat various neuropathologies. The ayurvedic herb, Cannabis is one of the oldest botanicals known to humans and has been widely used. However, the comprehensive effect of Cannabis on various neuropathologies is not well established. Hence, this review presents effects of Cannabis on various neuropathologies.

Indexed as

Cannabidiol-CBDCannabigerol-CBG)CannabisCannabis congeners (Δ9-Tetrahydrocannabiorcol-THCNeurological disordersNeuropathologiesNeuroprotectionNeurotoxicity

Identifiers

PMID38876946
PMCPMC11282377

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.