Evidence map›Paper›PMID 38876796›Full record

ArticleLife science alliance2024

The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis.

Eric Nelius, Zheng Fan, Michal Sobecki, Ewelina Krzywinska, Shunmugam Nagarajan, Irina Ferapontova, Dagmar Gotthardt, Norihiko Takeda, Veronika Sexl, Christian Stockmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Phenotypic switching of gastrointestinal smooth muscle cells and the regulatory role of macrophages: a literature review.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eric NeliusInstitute of Anatomy, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-9689-6926
Zheng FanInstitute of Anatomy, University of Zurich, Zurich, Switzerland.
Michal SobeckiInstitute of Anatomy, University of Zurich, Zurich, Switzerland.
Ewelina KrzywinskaInstitute of Anatomy, University of Zurich, Zurich, Switzerland.
Shunmugam NagarajanInstitute of Anatomy, University of Zurich, Zurich, Switzerland.
Irina FerapontovaInstitute of Anatomy, University of Zurich, Zurich, Switzerland.
Dagmar GotthardtInstitute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.ORCID 0000-0002-8416-1236
Norihiko TakedaDivision of Cardiology and Metabolism, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan.
Veronika SexlUniversity of Innsbruck, Innsbruck, Austria.
Christian StockmannInstitute of Anatomy, University of Zurich, Zurich, Switzerland christian.stockmann@anatomy.uzh.ch.ORCID 0000-0002-9726-6838

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are critical for intestinal adaptation to microenvironmental challenges, and the gut mucosa is characterized by low oxygen. Adaptation to low oxygen is mediated by hypoxia-inducible transcription factors (HIFs), and the HIF-1α subunit shapes an ILC phenotype upon acute colitis that contributes to intestinal damage. However, the impact of HIF signaling in NKp46

Indexed as

ColitisFibrosisHypoxia-Inducible Factor 1, alpha SubunitLymphocytesMice, KnockoutNatural Cytotoxicity Triggering Receptor 1AnimalsAntigens, LyChronic DiseaseDisease Models, AnimalImmunity, InnateInflammationIntestinal MucosaIntestinesMaleMiceAntigens, LyHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitNatural Cytotoxicity Triggering Receptor 1Ncr1 protein, mouse

Identifiers

PMID38876796
PMCPMC11178940

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.