Characterization of Cwc2, U6 snRNA, and Prp8 interactions destabilized by Prp16 ATPase at the transition between the first and second steps of splicing.

Jadwiga Meissner, Katarzyna Eysmont, Katarzyna Matylla-Kulińska, Maria M Konarska

Abstract read

In one paragraph

Article in RNA (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Genetic relationship between Sjögren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis.Frontiers in cardiovascular medicine · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jadwiga Meissner *IMol, Polish Academy of Sciences, 02-247 Warsaw, Poland.ORCID 0009-0000-9612-6940

Katarzyna Eysmont *IMol, Polish Academy of Sciences, 02-247 Warsaw, Poland.ORCID 0000-0002-0732-2243

Katarzyna Matylla-KulińskaORCID 0000-0001-6731-3739

Maria M KonarskaIMol, Polish Academy of Sciences, 02-247 Warsaw, Poland m.konarska@imol.institute.ORCID 0000-0001-9235-1702

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spliceosome performs two consecutive transesterification reactions using one catalytic center, thus requiring its rearrangement between the two catalytic steps of splicing. The Prp16 ATPase facilitates exit from the first-step conformation of the catalytic center by destabilizing some interactions important for catalysis. To better understand rearrangements within the

Indexed as

RNA, Small NuclearRNA SplicingRNA Splicing FactorsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSpliceosomesAdenosine TriphosphatasesAllelesCatalytic DomainCryoelectron MicroscopyDEAD-box RNA HelicasesIntronsMutationProtein BindingRibonucleoprotein, U4-U6 Small NuclearRibonucleoprotein, U5 Small NuclearAdenosine TriphosphatasesCwc2 protein, S cerevisiaeDEAD-box RNA HelicasesPRP16 protein, S cerevisiaePRP8 protein, S cerevisiaeRibonucleoprotein, U4-U6 Small NuclearRibonucleoprotein, U5 Small NuclearRNA-Binding ProteinsRNA HelicasesRNA, Small NuclearRNA Splicing FactorsSaccharomyces cerevisiae ProteinsU6 small nuclear RNAPrp16Prp8spliceosomal catalytic centertransition-state conformationU6 snRNA

Identifiers

PMID38876504

DOI10.1261/rna.079886.123

PMCPMC11331412

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.