Evidence map›Paper›PMID 38876300›Full record

ArticleThe Journal of biological chemistry2024

The proteostasis interactomes of trafficking-deficient variants of the voltage-gated potassium channel K

Christian L Egly, Lea A Barny, Tri Do, Eli F McDonald, Björn C Knollmann, Lars Plate

Abstract read
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Christian L EglyDepartment of Medicine, Vanderbilt University Medical Center, Nasville, Tennessee, USA.
Lea A BarnyProgram in Chemical and Physical Biology, Vanderbilt University, Nashville, Tennessee, USA; Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Tri DoDepartment of Medicine, Vanderbilt University Medical Center, Nasville, Tennessee, USA.
Eli F McDonaldDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Björn C KnollmannDepartment of Medicine, Vanderbilt University Medical Center, Nasville, Tennessee, USA. Electronic address: bjorn.knollmann@vumc.org.
Lars PlateDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA; Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. Electronic address: lars.plate@vanderbilt.edu.

Funding

CLINICAL PHARMACOLOGY TRAINING PROGRAMT32GM007569 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Bjorn C Knollmann · 1985 to 2026
$12.4M
Institutional Career Development CoreKL2TR002245 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$9.3M
Toward a Mechanism-Based Approach to Treating Cardiac ArrhythmiaR35HL144980 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KNOLLMANN, BJORN C · 2019 to 2025
$7.1M
Coordination of chaperone interactions that dictate protein folding and traffickingR35GM133552 · NIGMS · VANDERBILT UNIVERSITY · PI Lars Plate · 2019 to 2026
$3.2M
Rational optimization of combinatorial therapies for the treatment of rare cystic fibrosis variantsR01HL167046 · NHLBI · PURDUE UNIVERSITY · PI Lars Plate, Jonathan Patrick Schlebach · 2023 to 2026
$2.7M
Molecular Chaperone Recognition of CFTR StabilityF31HL162483 · NHLBI · VANDERBILT UNIVERSITY · PI MCDONALD, ELI FRITZ · 2022 to 2023
$58k
NCATS NIH HHS KL2 TR002245NHLBI NIH HHS F31 HL162483NHLBI NIH HHS R01 HL167046NHLBI NIH HHS R35 HL144980NIGMS NIH HHS R35 GM133552NIGMS NIH HHS T32 GM007569
6 · The paper itself

Abstract

The voltage-gated potassium ion channel K

Indexed as

Long QT SyndromeProtein TransportProteostasisAnimalsERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelsHEK293 CellsHumansERG1 Potassium ChannelEther-A-Go-Go Potassium ChannelshERGinteractomeion channellong QT syndromemass spectrometrytrafficking

Identifiers

PMID38876300
PMCPMC11284683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.