Evidence map›Paper›PMID 38875703›Full record

ArticleJournal of the American Chemical Society2024

Fe/Thiol Cooperative Hydrogen Atom Transfer Olefin Hydrogenation: Mechanistic Insights That Inform Enantioselective Catalysis.

Sarah R Buzsaki, Savannah M Mason, Padmanabha V Kattamuri, Juan M I Serviano, Dinora N Rodriguez, Conner V Wilson, Drew M Hood, Jonathan D Ellefsen, Yen-Chu Lu, Jolie Kan and 3 more

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Asymmetric Reduction of Unactivated Alkenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Synthesis through C(spAccounts of chemical research · 2025
    Article
  10. Hydrodealkenylative C(spJournal of the American Chemical Society · 2025
    Article
  11. Article
  12. C(spCommunications chemistry · 2025
    Article
  13. Building Catalytic Reactions One Electron at a Time.Accounts of chemical research · 2024
    Article
  14. Directed Hydrogen Atom Transfer for Selective Reactions of Polyenols.Journal of the American Chemical Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sarah R BuzsakiDepartment of Chemistry, Rice University, Houston, Texas 77030, United States.ORCID 0000-0001-8398-0494
Savannah M MasonDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0009-0005-7470-4654
Padmanabha V KattamuriDepartment of Chemistry, Rice University, Houston, Texas 77030, United States.
Juan M I ServianoDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Dinora N RodriguezDepartment of Chemistry, Rice University, Houston, Texas 77030, United States.
Conner V WilsonDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Drew M HoodDepartment of Chemistry, Rice University, Houston, Texas 77030, United States.
Jonathan D EllefsenDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
Yen-Chu LuDepartment of Chemistry, Rice University, Houston, Texas 77030, United States.
Jolie KanDepartment of Chemistry, Rice University, Houston, Texas 77030, United States.
Julian G WestDepartment of Chemistry, Rice University, Houston, Texas 77030, United States.ORCID 0000-0002-3715-7883
Scott J MillerDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0001-7817-1318
Patrick L HollandDepartment of Chemistry, Yale University, New Haven, Connecticut 06520, United States.ORCID 0000-0002-2883-2031

Funding

Site-Selective Catalysis for Bioactive Scaffold DiversificationR35GM132092 · NIGMS · YALE UNIVERSITY · PI Scott J Miller · 2019 to 2026
$6.3M
New Frontiers in Chemical Reactivity Via Catalytic Hydrogen Atom TransferR35GM142738 · NIGMS · RICE UNIVERSITY · PI Julian G West · 2021 to 2026
$2.3M
Mechanistically guided improvement in radical alkene coupling by base metal catalystsR01GM129081 · NIGMS · YALE UNIVERSITY · PI HOLLAND, PATRICK L · 2019 to 2022
$1.2M
NIGMS NIH HHS R01 GM129081NIGMS NIH HHS R35 GM132092NIGMS NIH HHS R35 GM142738
6 · The paper itself

Abstract

Asymmetric hydrogenation of activated olefins using transition metal catalysis is a powerful tool for the synthesis of complex molecules, but traditional metal catalysts have difficulty with enantioselective reduction of electron-neutral, electron-rich, and minimally functionalized olefins. Hydrogenation based on radical, metal-catalyzed hydrogen atom transfer (mHAT) mechanisms offers an outstanding opportunity to overcome these difficulties, enabling the mild reduction of these challenging olefins with selectivity that is complementary to traditional hydrogenations with H

Identifiers

PMID38875703
PMCPMC11209773

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.