Evidence map›Paper›PMID 38875504›Full record

ArticleBlood2024

Early-life infection depletes preleukemic cells in a mouse model of hyperdiploid B-cell acute lymphoblastic leukemia.

Ali Farrokhi, Tanmaya Atre, Samuel Salitra, Maryam Aletaha, Ana Citlali Márquez, Matthew Gynn, Mario Fidanza, Sumin Jo, Nina Rolf, Karen Simmons and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Ali FarrokhiMichael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, Canada.ORCID 0000-0002-6345-5585
Tanmaya AtreMichael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, Canada.ORCID 0000-0001-9863-691X
Samuel SalitraMichael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, Canada.ORCID 0000-0003-3389-228X
Maryam AletahaMichael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Ana Citlali MárquezMichael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Matthew GynnMichael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Mario FidanzaMichael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Sumin JoMichael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, Canada.ORCID 0000-0003-1445-9392
Nina RolfMichael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, Canada.ORCID 0000-0002-4531-2994
Karen SimmonsDivision of Infectious Diseases, Department of Pediatrics, The University of British Columbia, Vancouver, BC, Canada.
Jesus Duque-AfonsoDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA.ORCID 0000-0002-8287-5673
Michael L ClearyDepartment of Pathology, School of Medicine, Stanford University, Stanford, CA.
Alix E SeifAbramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-1799-2582
Tobias KollmannDepartment of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0003-2403-9762
Soren GanttDepartment of Microbiology, Infection, and Immunology, Université de Montreal, Montreal, QC, Canada.
Gregor S D ReidMichael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, Canada.ORCID 0000-0002-7567-3424

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractEpidemiological studies report opposing influences of infection on childhood B-cell acute lymphoblastic leukemia (B-ALL). Although infections in the first year of life appear to exert the largest impact on leukemia risk, the effect of early pathogen exposure on the fetal preleukemia cells (PLC) that lead to B-ALL has yet to be reported. Using cytomegalovirus (CMV) infection as a model early-life infection, we show that virus exposure within 1 week of birth induces profound depletion of transplanted E2A-PBX1 and hyperdiploid B-ALL cells in wild-type recipients and in situ-generated PLC in Eμ-ret mice. The age-dependent depletion of PLC results from an elevated STAT4-mediated cytokine response in neonates, with high levels of interleukin (IL)-12p40-driven interferon (IFN)-γ production inducing PLC death. Similar PLC depletion can be achieved in adult mice by impairing viral clearance. These findings provide mechanistic support for potential inhibitory effects of early-life infection on B-ALL progression and could inform novel therapeutic or preventive strategies.

Indexed as

Disease Models, AnimalPrecursor B-Cell Lymphoblastic Leukemia-LymphomaAnimalsAnimals, NewbornCytomegalovirus InfectionsDiploidyMiceMice, Inbred C57BLPreleukemia

Identifiers

PMID38875504
PMCPMC11375503

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.