ArticlePloS one2024
A bioelectronic device for electric field treatment of wounds reduces inflammation in an in vivo mouse model.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- A multi therapy bioelectronic wound dressing.npj biomedical innovations · 2026Article
- Electrical Microenvironment Reconstruction and the Application of Biomaterials in Spinal Cord Injury.Journal of functional biomaterials · 2026Review
- Advances in electroactive materials-based strategies for promoting skin wound healing.Frontiers in medical technology · 2026Review
- Towards adaptive bioelectronic wound therapy with integrated real-time diagnostics and machine learning-driven closed-loop control.npj biomedical innovations · 2025Article
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
Electrical signaling plays a crucial role in the cellular response to tissue injury in wound healing and an external electric field (EF) may expedite the healing process. Here, we have developed a standalone, wearable, and programmable electronic device to administer a well-controlled exogenous EF, aiming to accelerate wound healing in an in vivo mouse model to provide pre-clinical evidence. We monitored the healing process by assessing the re-epithelization rate and the ratio of M1/M2 macrophage phenotypes through histology staining. Following three days of treatment, the M1/M2 macrophage ratio decreased by 30.6% and the re-epithelization in the EF-treated wounds trended towards a non-statically significant 24.2% increase compared to the control. These findings provide point towards the effectiveness of the device in shortening the inflammatory phase by promoting reparative macrophages over inflammatory macrophages, and in speeding up re-epithelialization. Our wearable device supports the rationale for the application of programmed EFs for wound management in vivo and provides an exciting basis for further development of our technology based on the modulation of macrophages and inflammation to better wound healing.
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Registered trials
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