Evidence map›Paper›PMID 38875147›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Elongasome core proteins and class A PBP1a display zonal, processive movement at the midcell of

Amilcar J Perez, Melissa M Lamanna, Kevin E Bruce, Marc A Touraev, Julia E Page, Sidney L Shaw, Ho-Ching Tiffany Tsui, Malcolm E Winkler

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. [Advances in the Regulation of Protein Phosphorylation in Streptococcal Cell Wall Synthesis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. SpoIIE drives asymmetric cell division inbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. How do spherical bacteria regulate cell division?Biochemical Society transactions · 2025
    Review
  8. Bacterial peptidoglycan as a living polymer.Current opinion in chemical biology · 2025
    Review
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Amilcar J Perez *Department of Biology, Indiana University Bloomington, Bloomington, IN 47405.ORCID 0000-0001-6729-7564
Melissa M Lamanna *Department of Biology, Indiana University Bloomington, Bloomington, IN 47405.ORCID 0000-0002-6535-7903
Kevin E Bruce *Department of Biology, Indiana University Bloomington, Bloomington, IN 47405.ORCID 0009-0005-3300-8863
Marc A TouraevDepartment of Biology, Indiana University Bloomington, Bloomington, IN 47405.ORCID 0000-0001-8351-6413
Julia E PageDepartment of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-9884-2382
Sidney L ShawDepartment of Biology, Indiana University Bloomington, Bloomington, IN 47405.ORCID 0000-0001-9195-6128
Ho-Ching Tiffany TsuiDepartment of Biology, Indiana University Bloomington, Bloomington, IN 47405.ORCID 0000-0003-0849-874X
Malcolm E WinklerDepartment of Biology, Indiana University Bloomington, Bloomington, IN 47405.ORCID 0000-0002-1482-2588

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Discovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infectionsR01AI148752 · NIAID · HARVARD MEDICAL SCHOOL · PI Daniel Kahne, Suzanne Walker · 2020 to 2026
$5.5M
New Regulatory Interactions and Circuits that Mediate the Dynamics, Homeostasis, and Stress Responses of Peptidoglycan Synthesis in the Superbug Streptococcus pneumoniaeR35GM131767 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI MALCOLM E. WINKLER · 2019 to 2026
$4.8M
Graduate Program in Quantitative and Chemical Biology at Indiana University BloomT32GM109825 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI GIEDROC, DAVID P. · 2014 to 2018
$926k
Acquisition of a DeltaVision OMX-SR Imaging SystemS10OD024988 · OD · INDIANA UNIVERSITY INDIANAPOLIS · PI WALCZAK, CLAIRE E · 2018 to 2018
$600k
Understanding the Regulation and Biological Roles of Peptidoglycan Hydrolases in Staphylococcus aureusF30AI156972 · NIAID · HARVARD MEDICAL SCHOOL · PI PAGE, JULIA ELAINE · 2021 to 2023
$142k
Investigation of the essential, conserved RodZ protein in peptidoglycan synthesis in the ovococcal pathogen, Streptococcus pneumoniaeF31AI138430 · NIAID · TRUSTEES OF INDIANA UNIVERSITY · PI LAMANNA, MELISSA MAE · 2018 to 2020
$90k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) F30AI156972HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) F31AI138430HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) RO1AI148752HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM131767HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM007753HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM109825HHS | NIH | NIH Office of the Director (OD) S10OD024988NIAID NIH HHS F30 AI156972NIAID NIH HHS F31 AI138430NIAID NIH HHS R01 AI148752NIGMS NIH HHS R35 GM131767NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM109825NIH HHS S10 OD024988NSF | BIO | Division of Molecular and Cellular Biosciences (MCB) MCB1027504
6 · The paper itself

Abstract

Ovoid-shaped bacteria, such as

Indexed as

Bacterial ProteinsPenicillin-Binding ProteinsStreptococcus pneumoniaePeptidoglycanPeptidoglycan GlycosyltransferaseBacterial ProteinsPenicillin-Binding ProteinsPeptidoglycanPeptidoglycan Glycosyltransferaseclass A PBP circumferential movementdiffusion of nonactive PG synthesis proteinsMpgA muramidase confined subdiffusionPBP2b:RodA:MreC elongasome dynamicsprocessive movement of PG synthesis proteins

Identifiers

PMID38875147
PMCPMC11194595

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.