Evidence map›Paper›PMID 38875132›Full record

ArticleThe international journal of neuropsychopharmacology2024

NREM Slow-Wave Activity in Adolescents Is Differentially Associated With ADHD Levels and Normalized by Pharmacological Treatment.

Vivien Reicher, Orsolya Szalárdy, Róbert Bódizs, Blanka Vojnits, Tárek Zoltán Magyar, Mária Takács, János M Réthelyi, Nóra Bunford

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Article in The international journal of neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Vivien ReicherClinical and Developmental Neuropsychology Research Group, Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary.
Orsolya SzalárdyInstitute of Behavioural Sciences, Semmelweis University, Budapest, Hungary.
Róbert BódizsInstitute of Behavioural Sciences, Semmelweis University, Budapest, Hungary.
Blanka VojnitsInstitute of Behavioural Sciences, Semmelweis University, Budapest, Hungary.
Tárek Zoltán MagyarInstitute of Behavioural Sciences, Semmelweis University, Budapest, Hungary.
Mária TakácsClinical and Developmental Neuropsychology Research Group, Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary.
János M RéthelyiDepartment of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.
Nóra BunfordClinical and Developmental Neuropsychology Research Group, Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Budapest, Hungary.ORCID 0000-0002-9645-604X

Funding

Hungarian Academy of Sciences 61831Z0100Hungarian Academy of Sciences Hungarian Brain Research Program HAS-ELRN NAP2022-I-2/2022National Research, Development and Innovation Office #RRF-2.3.1-21-2022-00011
6 · The paper itself

Abstract

backgroundA compelling hypothesis about attention-deficit/hyperactivity disorder (ADHD) etiopathogenesis is that the ADHD phenotype reflects a delay in cortical maturation. Slow-wave activity (SWA) of non-rapid eye movement (NREM) sleep electroencephalogram (EEG) is an electrophysiological index of sleep intensity reflecting cortical maturation. Available data on ADHD and SWA are conflicting, and developmental differences, or the effect of pharmacological treatment, are relatively unknown.

methodsWe examined, in samples (Mage = 16.4, SD = 1.2), of ever-medicated adolescents at risk for ADHD (n = 18; 72% boys), medication-naïve adolescents at risk for ADHD (n = 15, 67% boys), and adolescents not at risk for ADHD (n = 31, 61% boys) matched for chronological age and controlling for non-ADHD pharmacotherapy, whether ADHD pharmacotherapy modulates the association between NREM SWA and ADHD risk in home sleep.

resultsFindings indicated medication-naïve adolescents at risk for ADHD exhibited greater first sleep cycle and entire night NREM SWA than both ever-medicated adolescents at risk for ADHD and adolescents not at risk for ADHD and no difference between ever-medicated, at-risk adolescents, and not at-risk adolescents.

conclusionsResults support atypical cortical maturation in medication-naïve adolescents at risk for ADHD that appears to be normalized by ADHD pharmacotherapy in ever-medicated adolescents at risk for ADHD. Greater NREM SWA may reflect a compensatory mechanism in middle-later adolescents at risk for ADHD that normalizes an earlier occurring developmental delay.

Indexed as

Attention Deficit Disorder with HyperactivityElectroencephalographyAdolescentCentral Nervous System StimulantsFemaleHumansMaleSleep, Slow-WaveSleep StagesCentral Nervous System StimulantsADHDDREEM2 headbandmedicationSleep EEGslow-wave activity

Identifiers

PMID38875132
PMCPMC11232459

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.