ArticlePlant cell reports2024
Heat-stress-responsive HvHSFA2e gene regulates the heat and drought tolerance in barley through modulation of phytohormone and secondary metabolic pathways.
Article in Plant cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Bacterial extracellular vesicles as emerging biostimulants in plant microbe signaling and stress tolerance.World journal of microbiology & biotechnology · 2026Review
- Mulberry ERF Transcription Factor MnERF23 Is a Positive Regulator of Plant Drought Tolerance.Plants (Basel, Switzerland) · 2026Article
- Molecular Mechanisms in Responses to Combined Stresses in Strawberry.Current issues in molecular biology · 2026Review
- Temperature regulation in plants: From molecular mechanisms to climate-resilient crop improvement.Journal of integrative plant biology · 2026Review
- CIRCADIAN CLOCK-ASSOCIATED 1 represses thermotolerance by inhibitingHorticulture research · 2026Article
- Molecular docking of the DREB(A-6) group and enhanced thermotolerance in potato by overexpressing the DREB(A-6) gene.Journal of plant research · 2026Article
- Integrated Analysis Reveals Functional Ingredients Biosynthesis and Regulatory Mechanisms inFood science & nutrition · 2026Article
- Genome-Wide Identification and Systematic Analysis of theInternational journal of molecular sciences · 2026Article
- Transcriptome and miRNAome analysis reveals expression profiles of platycodin biosynthesis-related genes and their potential miRNA regulators inFrontiers in plant science · 2026Article
- Review
- Long-term heat stress induces transcriptomic reprogramming of hormone signaling and metabolic pathways during rapeseed flowering.Scientific reports · 2025Article
- Genome-Wide Identification, Phylogenetic Classification, and Expression Profiling of the HSF Gene Family inPlants (Basel, Switzerland) · 2025Article
- Genetic insights into the synergistic effects of nano-iron on yield, quality, and antioxidant defense in barley under salt stress.Molecular genetics and genomics : MGG · 2025Article
- Priming thermotolerance: unlocking heat resilience for climate-smart crops.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Inherited endurance: deciphering genetic associations of transgenerational and intergenerational heat stress memory in barley.Plant molecular biology · 2025Article
- Comparative transcriptome and metabolome profiling unveil genotype-specific strategies for drought tolerance in cotton.Frontiers in plant science · 2025Article
- Heat stress suppresses DNA replication and mitosis in barley root apical meristems.Frontiers in plant science · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
key messageThe heat stress transcription factor HSFA2e regulates both temperature and drought response via hormonal and secondary metabolism alterations. High temperature and drought are the primary yield-limiting environmental constraints for staple food crops. Heat shock transcription factors (HSF) terminally regulate the plant abiotic stress responses to maintain growth and development under extreme environmental conditions. HSF genes of subclass A2 predominantly express under heat stress (HS) and activate the transcriptional cascade of defense-related genes. In this study, a highly heat-inducible HSF, HvHSFA2e was constitutively expressed in barley (Hordeum vulgare L.) to investigate its role in abiotic stress response and plant development. Transgenic barley plants displayed enhanced heat and drought tolerance in terms of increased chlorophyll content, improved membrane stability, reduced lipid peroxidation, and less accumulation of ROS in comparison to wild-type (WT) plants. Transcriptome analysis revealed that HvHSFA2e positively regulates the expression of abiotic stress-related genes encoding HSFs, HSPs, and enzymatic antioxidants, contributing to improved stress tolerance in transgenic plants. The major genes of ABA biosynthesis pathway, flavonoid, and terpene metabolism were also upregulated in transgenics. Our findings show that HvHSFA2e-mediated upregulation of heat-responsive genes, modulation in ABA and flavonoid biosynthesis pathways enhance drought and heat stress tolerance.
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