Evidence map›Paper›PMID 38874704›Full record

ArticleMolecular neurobiology2025

Mitochondrial Uncoupling Protein-2 Ameliorates Ischemic Stroke by Inhibiting Ferroptosis-Induced Brain Injury and Neuroinflammation.

Lei Wang, Xiaona Li, Lili Chen, Shenglan Mei, Qianni Shen, Lian Liu, Xuke Liu, Shichong Liao, Bo Zhao, Yannan Chen and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Deciphering Uncoupling Proteins in Cellular Homeostasis and Metabolic Health.International journal of biological sciences · 2026
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lei WangDepartment of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Xiaona LiDepartment of Pain Medicine, Wuhan Fourth Hospital, Wuhan, 430033, China.
Lili ChenDepartment of Anesthesiology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, P.O. Box 430060, Wuhan, 430060, China.
Shenglan MeiDepartment of Anesthesiology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, P.O. Box 430060, Wuhan, 430060, China.
Qianni ShenDepartment of Anesthesiology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, P.O. Box 430060, Wuhan, 430060, China.
Lian LiuDepartment of Anesthesiology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, P.O. Box 430060, Wuhan, 430060, China.
Xuke LiuDepartment of Anesthesiology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, P.O. Box 430060, Wuhan, 430060, China.
Shichong LiaoDepartment of Thyroid and Breast Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Bo ZhaoDepartment of Anesthesiology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, P.O. Box 430060, Wuhan, 430060, China.
Yannan ChenDepartment of Endocrinology, Wuhan Fourth Hospital, Wuhan, 430033, China.
Jiabao HouDepartment of Anesthesiology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, P.O. Box 430060, Wuhan, 430060, China. bohrhou@whu.edu.cn.ORCID http://orcid.org/0000-0002-7314-0907

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke is a devastating disease in which mitochondrial damage or dysfunction substantially contributes to brain injury. Mitochondrial uncoupling protein-2 (UCP2) is a member of the UCP family, which regulates production of mitochondrial superoxide anion. UCP2 is reported to be neuroprotective for ischemic stroke-induced brain injury. However, the molecular mechanisms of UCP2 in ischemic stroke remain incompletely understood. In this study, we investigated whether and how UCP2 modulates neuroinflammation and regulates neuronal ferroptosis following ischemic stroke in vitro and in vivo. Wild-type (WT) and UCP2 knockout (Ucp2

Indexed as

FerroptosisIschemic StrokeMice, Inbred C57BLMice, KnockoutNeuroinflammatory DiseasesUncoupling Protein 2AnimalsBrain InjuriesCell LineInfarction, Middle Cerebral ArteryMaleMiceMicrogliaNeuronsUcp2 protein, mouseUncoupling Protein 2FerroptosisGPX4Ischemia strokeLipid peroxidationNeuroinflammationOxidative stressUCP2

Identifiers

PMID38874704

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.