Evidence map›Paper›PMID 38874448›Full record

ArticleAlimentary pharmacology & therapeutics2024

Characterisation of an outbreak of acute liver injury after ingestion of plant-based food supplement.

Gina Choi, Jawad Ahmad, Victor Navarro, Swan Thung, Ikhlas Khan, Bharathi Avula, Huiman Barnhart, Andrew Stolz, Drug‐Induced Liver Injury Network

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alimentary pharmacology & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Research progress in the field of drug-induced liver injury in the year 2024].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gina ChoiDavid Geffen School of Medicine, University of California, Los Angeles, California, USA.
Jawad AhmadIcahn School of Medicine, Mt. Sinai Health, New York, New York, USA.ORCID 0000-0003-1384-2349
Victor NavarroEinstein Healthcare Network, Jefferson Health, Philadelphia, Pennsylvania, USA.
Swan ThungIcahn School of Medicine, Mt. Sinai Health, New York, New York, USA.
Ikhlas KhanUniversity of Mississippi, Jackson, Mississippi, USA.
Bharathi AvulaUniversity of Mississippi, Jackson, Mississippi, USA.
Huiman BarnhartDuke University School of Medicine, Durham, North Carolina, USA.
Andrew StolzUniversity of Southern California, Los Angeles, California, USA.ORCID 0000-0002-1443-9351
Drug‐Induced Liver Injury Network

Funding

Drug Induced Liver Injury Network Data Coordinating CenterU01DK065176 · NIDDK · DUKE UNIVERSITY · PI Huiman X Barnhart · 2003 to 2026
$25.5M
Coordinating Center for the Drug Induced Liver Injury Network (DILIN)U24DK065176 · NIDDK · DUKE UNIVERSITY · PI BARNHART, HUIMAN X · 2018 to 2022
$7.6M
IU Clinical Center: Drug Induced Liver Injury NetworkU01DK065211 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NAGA P CHALASANI · 2003 to 2026
$7.5M
University of North Carolina Clinical Center for DILINU01DK065201 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PAUL B WATKINS · 2003 to 2026
$7.3M
Michigan Hepatotoxicity Clinical Research Network Renewal 2018U01DK065184 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROBERT J FONTANA · 2003 to 2026
$7.0M
The Drug Induced Liver Injury Network (DILIN): Focus on Herbal and DietarySupplementsU01DK083027 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI Dina Halegoua-DeMarzio · 2008 to 2026
$7.0M
USC-UCLA Drug-Induced Liver Injury (DILI) Clinical Center.U01DK083020 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Lily Dara · 2008 to 2026
$5.9M
Mount Sinai Regional Drug Induced Liver Injury Network SiteU01DK100928 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AHMAD, JAWAD, ODIN, JOSEPH · 2013 to 2022
$4.0M
NIDDK NIH HHS U01 DK065176NIDDK NIH HHS U01 DK065184NIDDK NIH HHS U01 DK065201NIDDK NIH HHS U01 DK065211NIDDK NIH HHS U01 DK083020NIDDK NIH HHS U01DK083020NIDDK NIH HHS U01 DK083027NIDDK NIH HHS U01DK083027NIDDK NIH HHS U01 DK100928NIDDK NIH HHS U01DK100928NIDDK NIH HHS U24 DK065176NIDDK NIH HHS U24DK065176
6 · The paper itself

Abstract

backgroundIn April 2022, French Lentil and Leek Crumble (FLLC), a new frozen food preparation manufactured by Daily Harvest™ (containing Tara flour) was offered as a natural high-protein meal product. Soon thereafter, widespread anecdotal reports of acute gastrointestinal symptoms with liver injury were reported, leading to its voluntary withdrawal in June 2022, after shipment of 28,000 preparations.

aimsTo summarise the clinical and laboratory features of 17 patients with FLLC associated liver injury from the Drug Induced Liver Injury Network (DILIN).

methodsPatients with FLLC-associated liver injury were enrolled into a prospective protocol and followed for 6 months. Cases were adjudicated by expert opinion causality assessment with summary statistics for data analysis.

resultsEnrolled subjects had a mean age of 41 years, 82% were female with mean BMI of 24 kg/m

conclusionsNatural food products are increasingly ubiquitous and may unexpectedly cause significant illness. All clinicians should inquire whether patients are consuming natural food products or herbal supplements and consider them as a potential cause of liver injury.

Indexed as

Chemical and Drug Induced Liver InjuryDietary SupplementsDisease OutbreaksAdultFemaleHumansMaleMiddle AgedProspective StudiesYoung Adult

Identifiers

PMID38874448
PMCPMC11587764

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.