Evidence map›Paper›PMID 38874422›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Emerging 2D Nanomaterials-Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy.

Melanie Zorrón, Agustín López Cabrera, Riya Sharma, Janani Radhakrishnan, Samin Abbaszadeh, Mohammad-Ali Shahbazi, Omid Aghababaei Tafreshi, Solmaz Karamikamkar, Hajar Maleki

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

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  10. [Bioactive substances delivery for bone repair via nanocomposites: advantages, mechanisms, and emerging trends].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melanie ZorrónInstitute of Inorganic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Greinstraße 6, 50939, Cologne, Germany.
Agustín López CabreraInstitute of Inorganic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Greinstraße 6, 50939, Cologne, Germany.
Riya SharmaInstitute of Inorganic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Greinstraße 6, 50939, Cologne, Germany.
Janani RadhakrishnanDepartment of Biotechnology, National Institute of Animal Biotechnology, Hyderabad, 500 049, India.
Samin AbbaszadehDepartment of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, 571478334, Iran.
Mohammad-Ali ShahbaziDepartment of Biomaterials and Biomedical Technology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, Groningen, AV, 9713, The Netherlands.
Omid Aghababaei TafreshiMicrocellular Plastics Manufacturing Laboratory, Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario, M5S 3G8, Canada.
Solmaz KaramikamkarTerasaki Institute for Biomedical Innovation, 11570 W Olympic Boulevard, Los Angeles, CA, 90024, USA.
Hajar MalekiInstitute of Inorganic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Greinstraße 6, 50939, Cologne, Germany.ORCID 0000-0002-2813-4700

Funding

German Research Foundation 467116484
6 · The paper itself

Abstract

This review highlights recent advancements in the synthesis, processing, properties, and applications of 2D-material integrated hydrogels, with a focus on their performance in bone-related applications. Various synthesis methods and types of 2D nanomaterials, including graphene, graphene oxide, transition metal dichalcogenides, black phosphorus, and MXene are discussed, along with strategies for their incorporation into hydrogel matrices. These composite hydrogels exhibit tunable mechanical properties, high surface area, strong near-infrared (NIR) photon absorption and controlled release capabilities, making them suitable for a range of regeneration and therapeutic applications. In cancer therapy, 2D-material-based hydrogels show promise for photothermal and photodynamic therapies, and drug delivery (chemotherapy). The photothermal properties of these materials enable selective tumor ablation upon NIR irradiation, while their high drug-loading capacity facilitates targeted and controlled release of chemotherapeutic agents. Additionally, 2D-materials -infused hydrogels exhibit potent antibacterial activity, making them effective against multidrug-resistant infections and disruption of biofilm generated on implant surface. Moreover, their synergistic therapy approach combines multiple treatment modalities such as photothermal, chemo, and immunotherapy to enhance therapeutic outcomes. In bio-imaging, these materials serve as versatile contrast agents and imaging probes, enabling their real-time monitoring during tumor imaging. Furthermore, in bone regeneration, most 2D-materials incorporated hydrogels promote osteogenesis and tissue regeneration, offering potential solutions for bone defects repair. Overall, the integration of 2D materials into hydrogels presents a promising platform for developing multifunctional theragenerative biomaterials.

Indexed as

Bone RegenerationHydrogelsNanostructuresAnimalsDrug Delivery SystemsHumansHydrogels2D nanomaterialsbone cancer therapybone regenerationcompositeshydrogeltheragenerative materials

Identifiers

PMID38874422
PMCPMC11336986

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.