ArticleAnnals of clinical and translational neurology2024
Altered brain perfusion and oxygen levels relate to sleepiness and attention in post-COVID syndrome.
Article in Annals of clinical and translational neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Trial
- Cognition-Linked Monocyte State Reveals Altered Myeloid-Lymphoid Coordination in Neuro-PASC.International journal of molecular sciences · 2026Article
- Long-term cognitive outcomes after mild COVID-19, critical COVID-19, and non-COVID critical illness: a prospective cohort comparison.Scientific reports · 2026Observational
- Cognitive impairment in patients with middle cerebral artery severe stenosis or occlusion is associated with hemodynamic abnormalities.BMC neurology · 2026Observational
- Virus-induced endothelial senescence as a cause and driving factor for ME/CFS and long COVID: mediated by a dysfunctional immune system.Cell death & disease · 2026Review
- Assessment of dynamic cerebral blood flow changes during cognitive tasks in patients with post-COVID-19 syndrome.Brain communications · 2026Article
- Association of structural brain changes with cognitive deficits and fatigue in patients with post-COVID-19 condition.Brain communications · 2026Article
- Neuroimmune pathophysiology of long COVID.Psychiatry and clinical neurosciences · 2025Review
- Factors associated with reduction in quality of life after SARS-CoV-2 infection.Scientific reports · 2025Article
- Review
- Altered putamen connectivity in patients with neurological post-COVID condition.Brain communications · 2025Article
- Fatigue in Post-COVID-Condition is accompanied by hypoperfusion of right-occipital areas.PloS one · 2025Article
- Non-invasive Assessment of Cerebral Hemodynamics Using Resting-State Functional Magnetic Resonance Imaging in Multiple Sclerosis and Age-Related White Matter Lesions.Human brain mapping · 2024Article
- Overlapping conditions in Long COVID at a multisite academic center.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectivePersisting neurological symptoms after COVID-19 affect up to 10% of patients and can manifest in fatigue and cognitive complaints. Based on recent evidence, we evaluated whether cerebral hemodynamic changes contribute to post-COVID syndrome (PCS).
methodsUsing resting-state functional magnetic resonance imaging, we investigated brain perfusion and oxygen level estimates in 47 patients (44.4 ± 11.6 years; F:M = 38:9) and 47 individually matched healthy control participants. Group differences were calculated using two-sample t-tests. Multivariable linear regression was used for associations of each regional perfusion and oxygen level measure with cognition and sleepiness measures. Exploratory hazard ratios were calculated for each brain metric with clinical measures.
resultsPatients presented with high levels of fatigue (79%) and daytime sleepiness (45%). We found widespread decreased brain oxygen levels, most evident in the white matter (false discovery rate adjusted-p-value (p-
interpretationOur findings of lower regional brain blood oxygen levels suggest increased cerebral metabolism in PCS, which potentially holds a compensatory function. These hemodynamic changes were related to symptom severity, possibly representing metabolic adaptations.
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