ArticleThe ISME journal2024
Resistance towards and biotransformation of a Pseudomonas-produced secondary metabolite during community invasion.
Article in The ISME journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Synthetic microbial communities for studying the fate and ecological role of specialized metabolites.Essays in biochemistry · 2026Review
- When neighbors control metabolite fate: consequences for plant pathogen virulence and biocontrol outcomes.Applied and environmental microbiology · 2026Article
- Warfare among rice sheath pathogens:Applied and environmental microbiology · 2026Article
- Higher-Level Structural Classification of Pseudomonas Cyclic Lipopeptides through Their Bioactive Conformation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bridging ecological processes to elevated antibiotic resistance risk in tomato microbiome under fungicide stress.The ISME journal · 2026Article
- Bridging ecological processes to elevated antibiotic resistance risk in tomato microbiome under fungicide stress.The ISME journal · 2026Article
- Ecological function of phenazine in soil.Nature microbiology · 2025Article
- Combatting glufosinate-induced pepper toxicity: jasmonic acid recruiting rhizosphere bacterial strain Rhodococcus gordoniae.Microbiome · 2025Article
- Reducing redundancy and enhancing accuracy through a phylogenetically-informed microbial community metabolic modeling approach.Bioinformatics (Oxford, England) · 2025Article
- Surfactin facilitates establishment of Bacillus subtilis in synthetic communities.The ISME journal · 2025Article
- Stenotrophomonas maltophilia impedes Bacillus biocontrol of tomato wilt disease by degrading its lipopeptide antibiotics.The ISME journal · 2025Article
- Article
- Strong pairwise interactions do not drive interactions in a plant leaf associated microbial community.ISME communications · 2025Article
- Co-existence of two antibiotic-producing marine bacteria:Applied and environmental microbiology · 2024Article
- Unveiling the fungal diversity and associated secondary metabolism on black apples.Applied and environmental microbiology · 2024Article
- Does regulation hold the key to optimizing lipopeptide production inFrontiers in bioengineering and biotechnology · 2024Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The role of antagonistic secondary metabolites produced by Pseudomonas protegens in suppression of soil-borne phytopathogens has been clearly documented. However, their contribution to the ability of P. protegens to establish in soil and rhizosphere microbiomes remains less clear. Here, we use a four-species synthetic community (SynCom) in which individual members are sensitive towards key P. protegens antimicrobial metabolites (DAPG, pyoluteorin, and orfamide A) to determine how antibiotic production contributes to P. protegens community invasion and to identify community traits that counteract the antimicrobial effects. We show that P. protegens readily invades and alters the SynCom composition over time, and that P. protegens establishment requires production of DAPG and pyoluteorin. An orfamide A-deficient mutant of P. protegens invades the community as efficiently as wildtype, and both cause similar perturbations to community composition. Here, we identify the microbial interactions underlying the absence of an orfamide A mediated impact on the otherwise antibiotic-sensitive SynCom member, and show that the cyclic lipopeptide is inactivated and degraded by the combined action of Rhodococcus globerulus D757 and Stenotrophomonas indicatrix D763. Altogether, the demonstration that the synthetic community constrains P. protegens invasion by detoxifying its antibiotics may provide a mechanistic explanation to inconsistencies in biocontrol effectiveness in situ.
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Registered trials
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