Evidence map›Paper›PMID 38874038›Full record

Observational studyCurrent HIV research2024

Prevalence and Causes of Vitamin D Deficiency in a Cohort of Greek HIV-Infected Individuals: A Prospective, Single Center, Observational Study.

Theodoros Androutsakos, Marianna Politou, Sofia Boti, Theodoros Pittaras, Athanasios Kontos, Theodore Kordossis, Abraham Pouliakis, George Panayiotakopoulos

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Current HIV research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Theodoros AndroutsakosDepartment of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0003-2556-6230
Marianna PolitouHematology Laboratory-Blood Bank at the Aretaieion Hospital, Second Department of Hematology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Sofia BotiDepartment of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Theodoros PittarasHematology Laboratory-Blood Bank at the Aretaieion Hospital, Second Department of Hematology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Athanasios KontosDepartment of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Theodore KordossisDepartment of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Abraham PouliakisSecond Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
George PanayiotakopoulosDepartment of Pharmacology, Medical School, University of Patras, Patras, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitamin D deficiency and/or insufficiency (hypovitaminosis D) has been associated with several disorders including autoimmune diseases, like type 1 diabetes mellitus; cardiovascular diseases; neoplasms; obesity; insulin resistance, and type 2 diabetes mellitus. This problem is common in southern European countries, especially in elderly and institutionalized persons. In HIV-infected individuals, hypovitaminosis D has been correlated with various complications like tuberculosis, hyperparathyroidism, bone mass loss, premature atherosclerosis, and systemic arterial hypertension, deterioration of immune function, progression of the disease and overall mortality.

objectiveThe objective of this study was to examine the prevalence and causes of hypovitaminosis D in a cohort of Greek HIV-infected patients, as well as possible complications associated with it.

methodsAll patients attending our HIV unit for a period of 5 months were included in this study. Vitamin D status, medical anamnes, and laboratory tests were obtained at baseline; patients were followed for 3 years and HIV-related complications were noted. No patient received vitamin D supplementation during the follow-up period.

resultsHypovitaminosis D was common, with 83.7% of the patients showing levels below 30 ng/dl and 55.4% below 20 ng/dl. After multivariable analysis, age and duration of treatment were the only significant factors for low vitamin D levels. During follow-up, 26 patients exhibited a total of 34 HIV-related complications, the most common being pneumonocystis jiroveci pneumonia (PCP). Hypovitaminosis D showed a positive correlation with overall complications, PCP as well as wasting syndrome.

conclusionOverall, our study shows that hypovitaminosis D is common in HIV-infected individuals and should probably be treated as soon as possible to protect these patients from serious HIVrelated complications like PCP or wasting syndrome.

Indexed as

HIV InfectionsVitamin D DeficiencyAdultAgedFemaleGreeceHumansMaleMiddle AgedPrevalenceProspective StudiesVitamin DVitamin DHIVhypovitaminosis Dimmunodeficiency.pneumocystis jiroveci pneumoniavitamin Dwasting syndrome

Identifiers

PMID38874038

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.