Evidence map›Paper›PMID 38873728›Full record

ArticleJournal of hepato-biliary-pancreatic sciences2024

Extranodal extension influences prognosis in pancreatic body/tail cancer: A retrospective cohort study.

Min Kyu Sung, Jihyun Chun, Yejong Park, Bong Jun Kwak, Woohyung Lee, Ki Byung Song, Jae Hoon Lee, Song Cheol Kim, Seung Mo Hong, Dae Wook Hwang

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In one paragraph

Article in Journal of hepato-biliary-pancreatic sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Min Kyu SungDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Jihyun ChunDepartment of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Yejong ParkDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-8532-9531
Bong Jun KwakDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Woohyung LeeDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-8119-6943
Ki Byung SongDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-5422-5481
Jae Hoon LeeDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Song Cheol KimDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Seung Mo HongDepartment of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Dae Wook HwangDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-1749-038X

Funding

SUREILLANCE AND RESPONSE TO AVIAN AND PANDEMIC INFLUENZAU51IP000841 · IP · SECID FOUNDATION · PI BINO, SILVA · 2013 to 2015
$1.2M
Asan Institute for Life Sciences, Asan Medical Center 2022IP0841NCIRD CDC HHS U51 IP000841
6 · The paper itself

Abstract

background/purposeExtranodal extension (ENE) is an established prognostic factor in various malignancies, affecting survival in pancreatic head cancer (PHC). However, its significance in pancreatic body/tail cancer (PBTC) remains unclear. Therefore, we aimed to investigate the impact of ENE on PTBC prognosis.

methodsWe analyzed data collected from electronic medical records of patients with PBTC who underwent distal pancreatectomy at a single center between January 2011 and December 2015. The patients were categorized based on ENE presence and prognostic implications were evaluated using Kaplan-Meier survival curves and Cox proportional hazards model.

resultsPBTC cases involving lymph node (LN) metastasis and ENE exhibited significantly lower disease-free (DFS) and overall survival (OS) rates compared to cases without LN metastasis or ENE (median DFS; N0, 23 months; LN+/ENE-, 10 months; LN+/ENE+, 5 months; p < .001). No statistically significant difference was observed in DFS and OS rates between patients with N1/N2 in the group without ENE and those with ENE+. Multivariate analysis confirmed ENE as a significant adverse prognostic factor.

conclusionsENE significantly predicts poor prognosis in PBTC, particularly in cases with nodal metastasis. The current cancer staging system for PBTC should incorporate ENE status. Moreover, different staging systems should be considered for PHC and PBTC.

Indexed as

Extranodal ExtensionPancreatectomyPancreatic NeoplasmsAdultAgedDisease-Free SurvivalFemaleHumansLymphatic MetastasisMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesSurvival Rateextranodal extensionpancreatic cancerprognosissurvivalTNM staging system

Identifiers

PMID38873728
PMCPMC11503450

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.