Evidence map›Paper›PMID 38873275›Full record

ArticleResuscitation plus2024

Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial.

Anina F van de Koolwijk, Thijs S R Delnoij, Martje M Suverein, Brigitte A B Essers, Renicus C Hermanides, Luuk C Otterspoor, Carlos V Elzo Kraemer, Alexander P J Vlaar, Joris J van der Heijden, Erik Scholten and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Anina F van de KoolwijkDepartment of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands.
Thijs S R DelnoijDepartment of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands.
Martje M SuvereinDepartment of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands.
Brigitte A B EssersDepartment of Clinical Epidemiology and Medical Technical Assessment, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands.
Renicus C HermanidesDepartment of Cardiology, Isala Clinics, Zwolle, The Netherlands.
Luuk C OtterspoorDepartment of Intensive Care, Catharina Hospital, Eindhoven, The Netherlands.
Carlos V Elzo KraemerDepartment of Intensive Care, Leiden University Medical Center, Leiden University, Leiden, The Netherlands.
Alexander P J VlaarDepartment of Intensive Care, Amsterdam University Medical Center Location AMC, University, Amsterdam, Amsterdam, The Netherlands.
Joris J van der HeijdenDepartment of Intensive Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Erik ScholtenDepartment of Intensive Care, St. Antonius Hospital, Nieuwegein, The Netherlands.
Corstiaan A den UilDepartment of Intensive Care, Erasmus Medical Center, Erasmus University, Rotterdam, The Netherlands.
Dinis Dos Reis MirandaDepartment of Intensive Care, Erasmus Medical Center, Erasmus University, Rotterdam, The Netherlands.
Sakir AkinDepartment of Intensive Care, Haga Hospital, The Hague, The Netherlands.
Jesse de MetzDepartment of Intensive Care, OLVG, Amsterdam, The Netherlands.
Iwan C C van der HorstDepartment of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands.
Bjorn WinkensDepartment of Methodology & Statistics, Maastricht University, Maastricht, The Netherlands.
Jos G MaessenDepartment of Cardiothoracic Surgery, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands.
Roberto LorussoDepartment of Cardiothoracic Surgery, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands.
Marcel C G van de PollDepartment of Intensive Care Medicine, Maastricht University Medical Center+, Maastricht University, Maastricht, The Netherlands.
INCEPTION-investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Prospective, trial-based data comparing health-related quality of life (HRQoL) in patients surviving out-of-hospital cardiac arrest (OHCA) through extracorporeal cardiopulmonary resuscitation (ECPR) or conventional CPR (CCPR) are scarce. We aimed to determine HRQoL during 1-year after refractory OHCA in patients treated with ECPR and CCPR. Methods: We present a secondary analysis of the multicenter INCEPTION-trial, which studied the effectiveness of ECPR versus CCPR in patients with refractory OHCA. HRQoL was prospectively assessed using the EQ-5D-5L questionnaire. Poor HRQoL was pragmatically defined as an EQ-5D-5L health utility index (HUI) > 1 SD below the age-adjusted norm. We used mixed linear models to assess the difference in HRQoL over time and univariable analyses to assess factors potentially associated with poor HRQoL. Results: A total of 134 patients were enrolled, and hospital survival was 20% (27 patients). EQ-5D-5L data were available for 25 patients (5 ECPR and 20 CCPR). One year after OHCA, the estimated mean HUI was 0.73 (0.05) in all patients, 0.84 (0.12) in ECPR survivors, and 0.71 (0.05) in CCPR survivors (p-value 0.31). Eight (32%) survivors had a poor HRQoL. HRQoL was good in 17 (68%) patients, with 100% in ECPR survivors versus 60% in CCPR survivors (p-value 0.14). Conclusion: One year after refractory OHCA, 68% of the survivors had a good HRQoL. We found no statistically significant difference in HRQoL one year after OHCA in patients treated with ECPR compared to CCPR. However, numerical differences may be clinically relevant in favor of ECPR.

Indexed as

Extracorporeal cardiopulmonary resuscitationHealth-related quality of lifeOut-of-hospital cardiac arrestRefractory arrest

Identifiers

PMID38873275
PMCPMC11170473

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.