Evidence map›Paper›PMID 38873105›Full record

ArticleMaterials today. Bio2024

Injectable and high-strength PLGA/CPC loaded ALN/MgO bone cement for bone regeneration by facilitating osteogenesis and inhibiting osteoclastogenesis in osteoporotic bone defects.

Lei Huang, Peihao Cai, Mengxuan Bian, Jieqin Yu, Lan Xiao, Shunyi Lu, Jiayi Wang, Weisin Chen, Guanjie Han, Xingdong Xiang and 4 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Lei HuangDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Peihao CaiThe Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Mengxuan BianDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jieqin YuDepartment of Orthopedic Surgery, Zhejiang Provincial Hospital of Chinese Medicine, Hangzhou, Zhejiang Province, 310003, China.
Lan XiaoSchool of Medicine and Dentistry, Griffith University, Gold COast, QLD, 4222, Australia.
Shunyi LuDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jiayi WangDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Weisin ChenDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Guanjie HanDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xingdong XiangDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Xin LiuThe Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Libo JiangDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yulin LiThe Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Jian ZhangDepartment of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis (OP) can result in slower bone regeneration than the normal condition due to the imbalance between osteogenesis and osteoclastogenesis, making osteoporotic bone defects healing a significant clinical challenge. Calcium phosphate cement (CPC) is a promising bone substitute material due to its good osteoinductive activity, however, the drawbacks such as fragility, slow degradation rate and incapability to control bone loss restrict its application in osteoporotic bone defects treatment. Currently, we developed the PLGA electrospun nanofiber sheets to carry alendronate (ALN) and magnesium oxide nanoparticle (nMgO) into CPC, therefore, to obtain a high-strength bone cement (C/AM-PL/C). The C/AM-PL/C bone cement had high mechanical strength, anti-washout ability, good injection performance and drug sustained release capacity. More importantly, the C/AM-PL/C cement promoted the osteogenic differentiation of bone marrow mesenchymal stem cells and neovascularization via the release of Mg

Indexed as

Bone regenerationInjectable calcium phosphate cementOsteoporosisPLGA nanofiber

Identifiers

PMID38873105
PMCPMC11169522

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.