Evidence map›Paper›PMID 38873104›Full record

ArticleMaterials today. Bio2024

Melt electrowritten poly-lactic acid /nanodiamond scaffolds towards wound-healing patches.

Xixi Wu, Wenjian Li, Lara Herlah, Marcus Koch, Hui Wang, Romana Schirhagl, Małgorzata K Włodarczyk-Biegun

Abstract read
In one paragraph

Article in Materials today. Bio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xixi WuDepartment of Biomedical Engineering, University Medical Centre, Ant. Deusinglaan 1, 9713, AW, Groningen, the Netherlands.
Wenjian LiAdvanced Production Engineering, Engineering and Technology Institute of Groningen, Faculty of Science and Engineering, University of Groningen, Nijenborgh 4, 9747, AG, the Netherlands.
Lara HerlahDepartment of Biomedical Engineering, University Medical Centre, Ant. Deusinglaan 1, 9713, AW, Groningen, the Netherlands.
Marcus KochINM - Leibniz Institute for New Materials, Campus D2 2, 66123, Saarbrücken, Germany.
Hui WangNanostructured Materials and Interfaces, Zernike Institute for Advanced Materials, Faculty of Science and Engineering, University of Groningen, Nijenborgh 4, 9747, AG, the Netherlands.
Romana SchirhaglDepartment of Biomedical Engineering, University Medical Centre, Ant. Deusinglaan 1, 9713, AW, Groningen, the Netherlands.
Małgorzata K Włodarczyk-BiegunPolymer Science, Zernike Institute for Advanced Materials, Faculty of Science and Engineering, University of Groningen, Nijenborgh 4, 9747, AG, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multifunctional wound dressings, enriched with biologically active agents for preventing or treating infections and promoting wound healing, along with cell delivery capability, are highly needed. To address this issue, composite scaffolds with potential in wound dressing applications were fabricated in this study. The poly-lactic acid/nanodiamonds (PLA/ND) scaffolds were first printed using melt electrowriting (MEW) and then coated with quaternized β-chitin (QβC). The NDs were well-dispersed in the printed filaments and worked as fillers and bioactive additions to PLA material. Additionally, they improved coating effectiveness due to the interaction between their negative charges (from NDs) and positive charges (from QβC). NDs not only increased the thermal stability of PLA but also benefitted cellular behavior and inhibited the growth of bacteria. Scaffolds coated with QβC increased the effect of bacteria growth inhibition and facilitated the proliferation of human dermal fibroblasts. Additionally, we have observed rapid extracellular matrix (ECM) remodeling on QβC-coated PLA/NDs scaffolds. The scaffolds provided support for cell adhesion and could serve as a valuable tool for delivering cells to chronic wound sites. The proposed PLA/ND scaffold coated with QβC holds great potential for achieving fast healing in various types of wounds.

Indexed as

Melt electrowritingNanodiamondsQuaternized β-chitinWound healing

Identifiers

PMID38873104
PMCPMC11170272

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.