Evidence map›Paper›PMID 38873062›Full record

ArticleChemical science2024

β-Terrecyclene synthase constructs the quadrane backbone in terrecyclic acid biosynthesis.

Yongxiang Song, Wengui Wang, Jiafan Yang, Dewei Gao, John M Billingsley, Songtao Wang, Yiguang Zhu, Junfeng Wang, Jianhua Ju, Yan Yan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yongxiang SongKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences 164 West Xingang Road Guangzhou 510301 China yyan@scsio.ac.cn.
Wengui WangSchool of Chemistry and Chemical Engineering, University of Jinan 336 West Road of Nan Xinzhuang Jinan 250022 China.ORCID https://orcid.org/0000-0003-3702-6901
Jiafan YangKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences 164 West Xingang Road Guangzhou 510301 China yyan@scsio.ac.cn.
Dewei GaoDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles CA 90095 USA.ORCID https://orcid.org/0000-0002-6258-8378
John M BillingsleyDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles CA 90095 USA.
Songtao WangKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences 164 West Xingang Road Guangzhou 510301 China yyan@scsio.ac.cn.
Yiguang ZhuKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences 164 West Xingang Road Guangzhou 510301 China yyan@scsio.ac.cn.
Junfeng WangKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences 164 West Xingang Road Guangzhou 510301 China yyan@scsio.ac.cn.ORCID https://orcid.org/0000-0001-8914-5174
Jianhua JuKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences 164 West Xingang Road Guangzhou 510301 China yyan@scsio.ac.cn.ORCID https://orcid.org/0000-0001-7712-8027
Yan YanKey Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences 164 West Xingang Road Guangzhou 510301 China yyan@scsio.ac.cn.ORCID https://orcid.org/0000-0001-6073-9921
Yi TangDepartment of Chemical and Biomolecular Engineering, University of California Los Angeles CA 90095 USA.ORCID https://orcid.org/0000-0003-1597-0141

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quadrane sesquiterpenes featuring a distinctive tricyclic skeleton exhibit potent antimicrobial and anticancer activities. Although extensive studies have attempted to reveal the multistep carbocation rearrangement involved in the formation of the tricyclic quadrane scaffold, the exact biosynthetic pathway and chemical logic to generate the quadrane structure remains mysterious. Here we identified a novel sesquiterpene synthase that is capable of generating β-terrecyclene possessing the quadrane scaffold and characterized the biosynthetic pathway of a representative fungal quadrane terrecyclic acid. Further mutagenesis coupled with isotopically sensitive branching studies of this β-terrecyclene synthase provided insight into the mechanism involved in the formation of the quadrane scaffold.

Identifiers

PMID38873062
PMCPMC11168084

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.