ArticleExtracellular vesicle2024
A multi-organ, feto-maternal interface organ-on-chip, models pregnancy pathology and is a useful preclinical extracellular vesicle drug trial platform.
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Article in Extracellular vesicle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Recapitulating gestational progression: a high-throughput 3D bioprinted vascularized human placenta demonstrating stage-specific molecular and functional signatures of human pregnancy.Scientific reports · 2026Article
- Intrahepatic cholestasis of pregnancy and offspring neurodevelopment: bile acid-mediated mechanisms and long-term neurodevelopmental outcomes.Archives of gynecology and obstetrics · 2026Review
- Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs-On-Chips.Advanced biology · 2026Review
- Bridging the Gap Between Static Histology and Dynamic Organ-on-a-Chip Models.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Endocrine Disruptors at the Fetomaternal Interface: Insight From PBDE Studies and the Utility of Novel Approach Methods.Endocrinology · 2026Review
- Review
- Human Multi-Organ-on-a-Chip Platforms for Next-Generation Drug Delivery Strategies.Theranostics · 2026Review
- Beyond traditional models: microfluidic technologies for engineering the human placentaFrontiers in bioengineering and biotechnology · 2026Review
- Exposure to Extreme Heat Increases Preterm Birth Risk: Hypothetical Pathophysiological Mechanisms.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Exosomal Delivery of Interleukin-10 Reduces Infection-Associated Inflammation in a 3D-Printed Model of a Humanized Feto-Maternal Interface.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Microfluidic device successfully replaces traditional models of pregnancy associated drug pharmacokinetic studies.Pregnancy (Hoboken, N.J.) · 2025Article
- Group B streptococcal infections in pregnancy and early life.Clinical microbiology reviews · 2025Review
- Lead exposure at the feto-maternal interface: a cause for concern for fetal membrane trophoblasts.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- How can we advance drug delivery options using extracellular vesicles for pregnant women to reduce preterm birth?Expert opinion on drug delivery · 2025Article
- Modeling reproductive and pregnancy-associated tissues using organ-on-chip platforms: challenges, limitations, and the high throughput data frontier.Frontiers in bioengineering and biotechnology · 2025Review
- Design strategy primer for organ-on-chips.Biomaterials translational · 2025Article
- Extracellular RNA communication: A decade of NIH common fund support illuminates exRNA biology.Journal of extracellular vesicles · 2025Review
- Enhanced operation of female reproductive microphysiological system (MPS) for rapid mechanistic study.Micro and nano systems letters · 2025Article
- New approach methods on the bench side to accelerate clinical trials during pregnancy.Expert opinion on drug metabolism & toxicology · 2024Review
- Reproductive organ on-a-chip technologies and assessments of the fetal-maternal interface.Frontiers in lab on a chip technologies · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Melody SafarzadehDivision of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Lauren S RichardsonDivision of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Ananth Kumar KammalaDivision of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Angela MosebargerDivision of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Mohamed BettayebDivision of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Sungjin KimDepartment of Biomedical Engineering and Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA.
Po Yi LamDepartment of Biomedical Engineering and Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA.
Enkhtuya RadnaaDivision of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Arum HanDepartment of Biomedical Engineering and Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA.
Ramkumar MenonDivision of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Funding
UTMB WOMEN'S HEALTH RESEARCH SCHOLARS PROGRAMK12HD052023 · NICHD · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI BERENSON, ABBEY B · 2005 to 2023
$8.1MUTMB Women's Health Research Scholars ProgramK12AR084228 · NIAMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ABBEY B BERENSON · 2023 to 2026
$2.7MIntercellular interactions define cell migrations and transitions that maintain fetal membrane homeostasisR01HD100729 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HAN, ARUM, MENON, RAMKUMAR · 2020 to 2024
$2.6MDeveloping trimester-specific placenta organ-on-chips to model healthy and oxidative stress and inflammation-associated pathologiesR01HD110400 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Lauren Stafford Richardson · 2023 to 2026
$2.3MDeveloping extracellular vesicle based therapeutics against pre-term birth through the use of maternal-fetal interface on a chipUH3TR003283 · NCATS · TEXAS ENGINEERING EXPERIMENT STATION · PI HAN, ARUM, MENON, RAMKUMAR · 2023 to 2025
$2.3MDeveloping extracellular vesicle based therapeutics against pre-term birth through the use of maternal-fetal interface on a chipUG3TR003283 · NCATS · TEXAS ENGINEERING EXPERIMENT STATION · PI HAN, ARUM, MENON, RAMKUMAR · 2020 to 2021
$1.5MNCATS NIH HHS UG3 TR003283NCATS NIH HHS UH3 TR003283NIAMS NIH HHS K12 AR084228NICHD NIH HHS K12 HD052023NICHD NIH HHS R01 HD100729NICHD NIH HHS R01 HD110400
Abstract
Pregnant women and their fetuses are often excluded from clinical trials due to missing drug-related pre-clinical trial information at the human feto-maternal interface (FMi). The two interfaces-placenta/decidua and fetal membranes/decidua are gatekeepers of drug transport; however, testing their functions is impractical during pregnancy. Limitations of current
Indexed as
EVsFetal membraneInterleukin-10Microphysiological systemsPlacentapreterm birth
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.