Evidence map›Paper›PMID 38872420›Full record

ArticleCancer medicine2024

Diagnostic and prognostic significance of circulating secreted frizzled-related protein 5 in colorectal cancer.

Runhao Li, Saifei Liu, Kenny Yeo, Suzanne Edwards, Man Ying Li, Ryan Santos, Sima Kianpour Rad, Fangmeinuo Wu, Guy Maddern, Joanne Young and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Runhao LiSolid Tumour Group, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.ORCID 0000-0001-5577-049X
Saifei LiuSolid Tumour Group, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.
Kenny YeoAdelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Suzanne EdwardsSchool of Public Health, The University of Adelaide, Adelaide, South Australia, Australia.
Man Ying LiAdelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Ryan SantosAdelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Sima Kianpour RadSolid Tumour Group, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.
Fangmeinuo WuSolid Tumour Group, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.
Guy MaddernAdelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Joanne YoungSolid Tumour Group, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.
Yoko TomitaSolid Tumour Group, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.
Amanda TownsendSolid Tumour Group, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.
Kevin FenixAdelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
Ehud HaubenDiscipline of Surgery, The University of Adelaide, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.
Timothy PriceSolid Tumour Group, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.ORCID 0000-0002-3922-2693
Eric SmithSolid Tumour Group, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.ORCID 0000-0003-2958-3492

Funding

AusHealth RES-SFRP-01
6 · The paper itself

Abstract

backgroundSecreted Frizzled-Related Protein 5 (SFRP5) modulates Wnt signalling pathways, affecting diverse biological processes. We assessed the diagnostic and prognostic value of circulating SFRP5 (cSFRP5) in colorectal cancer (CRC)

methodsPlasma cSFRP5 concentrations were measured using enzyme-linked immunosorbent assay (ELISA) in healthy donors (n = 133), individuals diagnosed with CRC (n = 449), colorectal polyps (n = 85), and medical conditions in other organs including cancer, inflammation, and benign states (n = 64).

resultsPatients with CRC, polyps, and other conditions showed higher cSFRP5 levels than healthy individuals (p < 0.0001). Receiver operating characteristic curves comparing healthy donors with medical conditions, polyps and CRC were 0.814 (p < 0.0001), 0.763 (p < 0.0001) and 0.762 (p < 0.0001), respectively. In CRC, cSFRP5 correlated with patient age (p < 0.0001), tumour stage (p < 0.0001), and histological differentiation (p = 0.0273). Levels, adjusted for patient age, sex, plasma age and collection institution, peaked in stage II versus I (p < 0.0001), III (p = 0.0002) and IV (p < 0.0001), were lowest in stage I versus III (p = 0.0002) and IV (p = 0.0413), with no difference between stage III and IV. Elevated cSFRP5 levels predicted longer overall survival in stages II-III CRC (univariate: HR 1.82, 95% CI: 1.02-3.26, p = 0.024; multivariable: HR 2.34, 95% CI: 1.12-4.88, p = 0.015).

conclusionThis study confirms cSFRP5 levels are elevated in CRC compared to healthy control and reveals a correlation between elevated cSFRP5 and overall survival in stages II-III disease.

Indexed as

Adaptor Proteins, Signal TransducingBiomarkers, TumorColorectal NeoplasmsAdultAgedAged, 80 and overCase-Control StudiesFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisROC CurveSecreted Frizzled-Related ProteinsAdaptor Proteins, Signal TransducingBiomarkers, TumorSecreted Frizzled-Related ProteinsSFRP5 protein, humancolorectal cancerdiagnosisplasma biomarkerprognosisSFRP5

Identifiers

PMID38872420
PMCPMC11176579

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.