Evidence map›Paper›PMID 38872405›Full record

ArticleCancer medicine2024

Cross-sectional study of therapy-related expectations/concerns of patients with metastatic renal cell carcinoma and physicians in Japan.

Go Kimura, Yasuhisa Fujii, Takahiro Osawa, Yosuke Uchitomi, Kazunori Honda, Miki Kondo, Ariko Otani, Tetsuya Wako, Daisuke Kawai, Yoshihide Mitsuda and 2 more

Abstract read
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Go KimuraDepartment of Urology, Nippon Medical School Hospital, Tokyo, Japan.ORCID 0000-0003-0088-9324
Yasuhisa FujiiDepartment of Urology, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0002-6761-3229
Takahiro OsawaDepartment of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Yosuke UchitomiInnovation Center for Supportive, Palliative and Psychosocial Care, National Cancer Center Hospital, Tokyo, Japan.
Kazunori HondaDepartment of Clinical Oncology, Aichi Cancer Center, Nagoya, Japan.
Miki KondoDepartment of Nursing, National Cancer Center Hospital East, Kashiwa, Japan.
Ariko OtaniDepartment of Nursing, National Cancer Center Hospital East, Kashiwa, Japan.
Tetsuya WakoDepartment of Pharmacy, Nippon Medical School Hospital, Tokyo, Japan.
Daisuke KawaiEisai Co., Ltd., Tokyo, Japan.
Yoshihide MitsudaEisai Co., Ltd., Tokyo, Japan.
Naotaka SakashitaMedilead, Inc., Tokyo, Japan.
Nobuo ShinoharaDepartment of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.ORCID 0000-0002-6695-294X

Funding

Eisai Co., Ltd.
6 · The paper itself

Abstract

objectiveTo achieve patient-centricity in metastatic renal cell carcinoma (mRCC) treatment, it is essential to clarify the differences in perspectives between patients and physicians. This cross-sectional analysis of a web survey aimed to clarify the differences in expectations and concerns between mRCC patients and physicians regarding systemic mRCC therapy in Japan.

methodsSurveys from 83 patients and 165 physicians were analyzed.

resultsThe top three most significant differences in expectations of systemic therapy between patients and physicians (patient-based physician value) were "Chance of achieving treatment-free status" (-30.1%, p < 0.001), "Longer survival" (+25.8%, p < 0.001), and "Chance of eliminating all evidence of disease" (-25.6%, p < 0.001). The top three most significant differences in concerns for systemic therapy between patients and physicians (patient-based physician value) were "Lack of efficacy" (+36.1%, p < 0.001), "Lack of knowledge of treatment" (-28.2%, p < 0.001), and "Daily activities affected by side effects" (+22.3%, p < 0.001). Diarrhea, fatigue/malaise, and nausea/vomiting were patients' most distressing adverse events; 50.6% of patients had difficulty telling their physicians about adverse events such as fatigue, anxiety, and depression.

conclusionsThis study demonstrated a gap between patients with mRCC and physicians in their expectations and concerns for systemic therapy. Japanese patients with mRCC suffer from a number of adverse events, some of which are not shared with physicians. This study highlights the importance of communicating well with patients in clinical practice to achieve patient-centricity in systemic treatment for mRCC.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsAdultAgedAged, 80 and overCross-Sectional StudiesFemaleHumansJapanMaleMiddle AgedNeoplasm MetastasisPhysician-Patient RelationsPhysiciansSurveys and Questionnairespatient‐centricityrenal cell carcinomashared decision‐makingsystemic therapytreatment preference

Identifiers

PMID38872405
PMCPMC11176571

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.