Evidence map›Paper›PMID 38872364›Full record

ArticleCancer medicine2024

Fertility preservation in male adolescents with cancer (2011-2020): A retrospective study in China.

Shasha Liu, Qiling Wang, Wenbing Zhu, Zhou Zhang, Wenhao Tang, Huiqiang Sheng, Jigao Yang, Yushan Li, Xiaowei Liang, Tianqing Meng and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Shasha LiuHuman Sperm Bank, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Qiling WangNHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive, Science Institute, Guangdong Provincial Fertility Hospital, Guangzhou, Guangdong, China.
Wenbing ZhuReproductive and Genetic Hospital CITIC Xiangya, Changsha, Hunan, China.
Zhou ZhangNorthwest Women and Children's Hospital, Xian, Shaanxi, China.
Wenhao TangDepartment of Urology, Peking University Third Hospital, Beijing, China.
Huiqiang ShengZhejiang Mater Child and Reproductive Health Center, Zhejiang, Hangzhou, China.
Jigao YangHuman Sperm Bank, Chongqing Research Institute for Population and Family Planning Science and Technology, Chongqing, China.
Yushan LiHenan Human Sperm Bank, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Xiaowei LiangHuman Sperm Bank of National Research Institute for Family Planning, Beijing, China.
Tianqing MengHubei Province Human Sperm Bank, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Zhiqiang WangThe First Affiliated Hospital of Guangxi Medical University, Guilin, Guangxi, China.
Faxi LinThe First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Hao DongDepartment of Urological Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Xiaojin HeAnhui Provincial Human Sperm Bank, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Xianglong JiangJiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi, China.
Shanjun DaiThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Aiping ZhangHuman Sperm Bank of The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
Chunying SongSperm Bank, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, Shanxi, China.
Zuowen LiangThe First Hospital of Jilin University, Jilin, China.
Feng ZhangObstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Xiaojun WangMaternal and Child Health Hospital of Urumqi, Xinjiang, China.
Peiyu LiangThe First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Guihua GongHuman Sperm Bank of Chifeng Gynecology and Obstetrics Hospital, Chifeng, Inner Mongolia, China.
Xiaohong HuaiLiaoning Maternal and Child Health Hospital, Shenyang, Liaoning, China.
Yanyun WangLaboratory of Molecular Translational Medicine, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Fuping LiHuman Sperm Bank, Key Laboratory of Birth Defects and Related Diseases of Women and Children of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0001-5183-4214
Xinzong ZhangNHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive, Science Institute, Guangdong Provincial Fertility Hospital, Guangzhou, Guangdong, China.

Funding

Sichuan Science and Technology Program 2022YFS0045
6 · The paper itself

Abstract

backgroundAccording to the studies, more than 80% of pediatric patients with cancer can achieve a survival rate greater than 5 years; however, long-term chemotherapy and/or radiation therapy may seriously affect their reproductive ability. Fertility preservation in adolescents with cancer in China was initiated late, and related research is lacking. Analyze data to understand the current situation and implement measures to improve current practices.

methodsFrom 2011 to 2020, data on 275 male adolescents with cancer whose age ranged from 0 to 19 years old were collected from 16 human sperm banks for this retrospective study. Methods include comparing the basic situation of male adolescents with cancer, the distribution of cancer types, and semen quality to analyze the status of fertility preservation.

resultsThe mean age was 17.39 ± 1.46 years, with 13 cases (4.7%) aged 13-14 years and 262 cases (95.3%) aged 15-19 years. Basic diagnoses included leukemia (55 patients), lymphomas (76), germ cell and gonadal tumors (65), epithelial tumors (37), soft tissue sarcomas (14), osteosarcoma (7), brain tumors (5), and other cancers (16). There are differences in tumor types in different age stages and regions. The tumor type often affects semen quality, while age affects semen volume. Significant differences were found in sperm concentration and progressive motility before and after treatment (p < 0.001). Moreover, 90.5% of patients had sperm in their semen and sperm were frozen successfully in 244 patients (88.7%).

conclusionsThe aim of this study is to raise awareness of fertility preservation in male adolescents with cancer, to advocate for fertility preservation prior to gonadotoxic therapy or other procedures that may impair future fertility, and to improve the fertility status of future patients.

Indexed as

Fertility PreservationNeoplasmsSemen AnalysisAdolescentChildChinaCryopreservationHumansInfertility, MaleMaleRetrospective StudiesYoung Adultcancercryopreservationfertility preservationmale adolescentssemen quality

Identifiers

PMID38872364
PMCPMC11176585

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