ArticleGenetics, selection, evolution : GSE2024
Genomic analyses of withers height and linear conformation traits in German Warmblood horses using imputed sequence-level genotypes.
Article in Genetics, selection, evolution : GSE, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Targeted allele frequency tuning in breeding populations via alternative optimum contribution selection.Genetics · 2026Article
- Bayesian fine-mapping pinpoints candidate genes and pleiotropic loci of production traits from a chicken backcrossing scheme.BMC genomics · 2026Article
- Impact of Mutations in theInternational journal of molecular sciences · 2026Article
- Unraveling the genomic architecture of hock conformation defects in Pura Raza Española horses.Journal of animal science · 2026Article
- Comparison between SNP array and imputed data to estimate population structure and ROH hotspots in horse breeds.BMC genomics · 2025Article
- Connections Between Gene Polymorphism and Fetlock and Hock Measurements in Polish Sport Horses.International journal of molecular sciences · 2025Article
- Genome-wide association study reveals candidate loci on ECA1 and ECA9 for withers height in Friesian horses.Animal genetics · 2025Article
- Single-Step Genome-Wide Association Study of Factors for Evaluated and Linearly Scored Traits in Swedish Warmblood Horses.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- LCORL and STC2 Variants Increase Body Size and Growth Rate in Cattle and Other Animals.Genomics, proteomics & bioinformatics · 2025Article
- Agreement of the morphometric dimensions determined by traditional and image analysis methods for Arabian and Thoroughbred horses.Archives animal breeding · 2025Article
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11 authors.
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Abstract
backgroundBody conformation, including withers height, is a major selection criterion in horse breeding and is associated with other important traits, such as health and performance. However, little is known about the genomic background of equine conformation. Therefore, the aim of this study was to use imputed sequence-level genotypes from up to 4891 German Warmblood horses to identify genomic regions associated with withers height and linear conformation traits. Furthermore, the traits were genetically characterised and putative causal variants for withers height were detected.
resultsA genome-wide association study (GWAS) for withers height confirmed the presence of a previously known quantitative trait locus (QTL) on Equus caballus (ECA) chromosome 3 close to the LCORL/NCAPG locus, which explained 16% of the phenotypic variance for withers height. An additional significant association signal was detected on ECA1. Further investigations of the region on ECA3 identified a few promising candidate causal variants for withers height, including a nonsense mutation in the coding sequence of the LCORL gene. The estimated heritability for withers height was 0.53 and ranged from 0 to 0.34 for the conformation traits. GWAS identified significantly associated variants for more than half of the investigated conformation traits, among which 13 showed a peak on ECA3 in the same region as withers height. Genetic parameter estimation revealed high genetic correlations between these traits and withers height for the QTL on ECA3.
conclusionsThe use of imputed sequence-level genotypes from a large study cohort led to the discovery of novel QTL associated with conformation traits in German Warmblood horses. The results indicate the high relevance of the QTL on ECA3 for various conformation traits, including withers height, and contribute to deciphering causal mutations for body size in horses.
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