Evidence map›Paper›PMID 38872065›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Preoperative decreased physical activity is associated with greater postoperative pain: the mediating role of preoperative sleep disturbance.

Jenna M Wilson, Angelina R Franqueiro, Emily Rosado, Victoria R Falso, Dennis Muñoz-Vergara, Michael T Smith, Elizabeth B Klerman, Shiqian Shen, Kristin L Schreiber

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In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. At the Intersection of Pain and Sleep: a Roadmap for Preclinical Pain Research.Frontiers in pain research (Lausanne, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jenna M WilsonDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 45 Francis St, Boston, MA, 02115, USA. jwilson47@mgb.org.
Angelina R FranqueiroDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 45 Francis St, Boston, MA, 02115, USA.
Emily RosadoDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 45 Francis St, Boston, MA, 02115, USA.
Victoria R FalsoDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 45 Francis St, Boston, MA, 02115, USA.
Dennis Muñoz-VergaraDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Michael T SmithDepartment of Psychiatry, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Elizabeth B KlermanDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Shiqian ShenDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, USA.
Kristin L SchreiberDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, 45 Francis St, Boston, MA, 02115, USA.

Funding

Personalizing Perioperative Preventive Analgesia: Translational Studies Investigating the Biopsychosocial Underpinnings of Enhanced Pain PropensityR35GM128691 · NIGMS · STANFORD UNIVERSITY · PI KRISTIN SCHREIBER · 2018 to 2026
$4.3M
Prediction and Prevention of Persistent Post-Mastectomy PainK23GM110540 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHREIBER, KRISTIN · 2015 to 2018
$762k
Yoga for Persistent Post-Surgical PainK01AT012889 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI Dennis Muñoz-Vergara · 2024 to 2026
$408k
NCCIH NIH HHS K01 AT012889NIGMS NIH HHS K23 GM110540NIGMS NIH HHS R35 GM128691NIH HHS GM110540
6 · The paper itself

Abstract

purposeEngagement in physical activity (PA) is often associated with better sleep quality and less pain severity among patients diagnosed with breast cancer. However, less research has focused on whether patients' PA prior to breast surgery, including their perceived decrease in PA level, is associated with worse preoperative sleep quality, and subsequently, greater postoperative pain. This longitudinal study investigated whether patients' preoperative PA was associated with their postoperative pain. We also explored whether preoperative sleep disturbance partially mediated the relationship between preoperative PA and postoperative pain.

methodsPrior to breast surgery, patients self-reported both their overall level of PA and whether they perceived a decrease in their PA since the diagnosis/onset of treatment for cancer. Patients also completed a measure of preoperative sleep disturbance. Two weeks after surgery, patients completed a measure of postoperative surgical-area pain severity.

resultsOur results showed that preoperatively perceiving a decrease in PA level was significantly associated with greater preoperative sleep disturbance and postoperative pain. A mediation analysis revealed that the association between preoperative decreased PA and postoperative pain was partially mediated by preoperative sleep disturbance. Notably, patients' overall preoperative level of PA was not related to preoperative sleep disturbance or postoperative pain.

conclusionThese findings suggest that maintaining, or even increasing, PA after diagnosis/treatment may be more important than the absolute amount of PA that women engage in during the preoperative period. Potentially, some patients with breast cancer may benefit from a preoperative intervention focused on both maintaining PA and bolstering sleep quality.

Indexed as

Breast NeoplasmsExercisePostoperative PainPreoperative PeriodSleep Wake DisordersAdultAgedFemaleHumansLongitudinal StudiesMiddle AgedPain MeasurementSelf ReportSleep QualityBreast cancerPainPhysical activitySleep disturbanceSurgery

Identifiers

PMID38872065
PMCPMC11956697

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.