Evidence map›Paper›PMID 38872047›Full record

ArticleDrug delivery and translational research2025

Conventional and microfluidic methods: Design and optimization of lipid-polymeric hybrid nanoparticles for gene therapy.

Daniel González-García, Olga Tapia, Carmen Évora, Patricia García-García, Araceli Delgado

Abstract read
In one paragraph

Article in Drug delivery and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel González-GarcíaDepartment of Chemical Engineering and Pharmaceutical Technology, Universidad de La Laguna, La Laguna, 38200, Spain.ORCID 0009-0005-1083-2251
Olga TapiaInstitute of Biomedical Technologies (ITB), Center for Biomedical Research of the Canary Islands (CIBICAN), Universidad de La Laguna, La Laguna, 38200, Spain.ORCID 0000-0002-0802-7975
Carmen ÉvoraDepartment of Chemical Engineering and Pharmaceutical Technology, Universidad de La Laguna, La Laguna, 38200, Spain.ORCID 0000-0002-9347-4672
Patricia García-GarcíaDepartment of Chemical Engineering and Pharmaceutical Technology, Universidad de La Laguna, La Laguna, 38200, Spain. pgarciag@ull.edu.es.ORCID 0000-0003-4801-4404
Araceli DelgadoDepartment of Chemical Engineering and Pharmaceutical Technology, Universidad de La Laguna, La Laguna, 38200, Spain. adelgado@ull.edu.es.ORCID 0000-0001-7045-6933

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene therapy holds significant promise as a therapeutic approach for addressing a diverse range of diseases through the suppression of overexpressed proteins and the restoration of impaired cell functions. Developing a nanocarrier that can efficiently load and release genetic material into cells remains a challenge. The primary goal of this study is to develop formulations aimed to enhance the therapeutic potential of GapmeRs through technological approaches. To this end, lipid-polymeric hybrid nanoparticles (LPHNPs) with PLGA, DC-cholesterol, and DOPE-mPEG

Indexed as

Genetic TherapyLipidsNanoparticlesCholesterolHumansMicrofluidicsParticle SizePhosphatidylethanolaminesPolyethylene GlycolsPolylactic Acid-Polyglycolic Acid CopolymerCholesterolLipidsPhosphatidylethanolaminesPolyethylene GlycolsPolylactic Acid-Polyglycolic Acid CopolymerEndosomal escapeGene therapyLipid-polymeric hybrid nanoparticlesMicrofluidicsNanoparticles stability

Identifiers

PMID38872047
PMCPMC11782348

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.