Evidence map›Paper›PMID 38872019›Full record

ArticleSurgical endoscopy2024

Persistent hyperbilirubinemia following preoperative biliary stenting in patients undergoing anatomic hepatectomy predicts serious complications.

Megan Kirkland, Kevin Verhoeff, Uzair Jogiat, Valentin Mocanu, A M James Shapiro, Blaire Anderson, David L Bigam, Khaled Dajani

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Article in Surgical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Megan KirklandFaculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Kevin VerhoeffDepartment of Surgery, University of Alberta, Edmonton, AB, Canada. verhoeff@ualberta.ca.ORCID 0000-0003-3110-5238
Uzair JogiatDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Valentin MocanuDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
A M James ShapiroDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Blaire AndersonDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
David L BigamDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.
Khaled DajaniDepartment of Surgery, University of Alberta, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBiliary obstruction before liver resection is a known risk factor for post-operative complications. The aim of this study was to determine the impact of persistent hyperbilirubinemia following preoperative biliary drainage before liver resection.

methodsThe ACS-NSQIP (2016-2021) database was used to extract patients with cholangiocarcinoma who underwent anatomic liver resection with preoperative biliary drainage comparing those with persistent hyperbilirubinemia (> 1.2 mg/dL) to those with resolution. Patient characteristics and outcomes were compared with bivariate analysis. Multivariable modeling evaluated factors including persistent hyperbilirubinemia to evaluate their independent effect on serious complications, liver failure, and mortality.

resultsWe evaluated 463 patients with 217 (46.9%) having hyperbilirubinemia (HB) despite biliary stenting. Bivariate analysis demonstrated that patients with HB had a higher rate of serious complications than those with non-HB (80.7% vs 70.3%; P = 0.010) including bile leak (40.9% vs 31.8%; P = 0.045), liver failure (26.7% vs 17.9%; P = 0.022), and bleeding (48.4% vs 36.6%; P = 0.010). Multivariable analysis demonstrated that persistent HB was independently associated with serious complications (OR 1.88, P = 0.020) and mortality (OR 2.39, P = 0.049) but not post-operative liver failure (OR 1.65, P = 0.082).

conclusionsFailed preoperative biliary decompression is a predictive factor for post-operative complications and mortality in patients undergoing hepatectomy and may be useful for preoperative risk stratification.

Indexed as

HepatectomyHyperbilirubinemiaPostoperative ComplicationsPreoperative CareStentsAgedBile Duct NeoplasmsCholangiocarcinomaCholestasisDrainageFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsBiliary obstructionHepatectomyHyperbilirubinemiaMajor hepatic resection

Identifiers

PMID38872019

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.